Cardiopulmonary exercise testing prognostic in aortic stenosis

August 25, 2017

(HealthDay)—For patients judged as symptomatic or questionably symptomatic for aortic stenosis, an initially conservative management strategy results in good prognosis if cardiopulmonary exercise testing (CPET) does not indicate significant hemodynamic compromise, according to a study published in the Sept. 1 issue of The American Journal of Cardiology.

Van D. Le, Ph.D., from Roskilde University Hospital in Denmark, and examined whether CPET is prognostically useful for patients judged asymptomatic or questionably symptomatic for aortic stenosis with aortic valve area index <0.6 cm²/m² and left ventricular ejection fraction ≥0.50. Participants were managed conservatively if they had normal peak oxygen consumption and peak oxygen pulse (group 1) or subnormal peak oxygen consumption or peak oxygen pulse with CPET data indicating pathologies other than hemodynamic compromise from aortic stenosis (group 2).

One hundred one were included (median age, 75 years) and 67 percent were judged as questionably symptomatic. The researchers found that the rates of unexpected cardiac death and unexpected hospitalization with heart failure were 0 and 6.0 percent, respectively, at a follow-up of 24 ± 6 months. All-cause mortality was 4 percent, relative to 8.0 percent in a population matched for age and gender. For groups 1 and 2, 37.1 and 38.7 percent, respectively, succumbed to cardiac death, or were hospitalized for heart failure, or underwent valve replacement.

"In conclusion, if CPET does not indicate a significant hemodynamic compromise because of , an initially conservative strategy results in a good prognosis and an acceptable event rate," the authors write.

Explore further: Study examines use, outcomes of valve replacement procedure performed for off-label indications

More information: Abstract
Full Text

Related Stories

Study examines use, outcomes of valve replacement procedure performed for off-label indications

June 21, 2017
Approximately 1 in 10 transcatheter aortic valve replacement (TAVR) procedures in the U.S. were for an off-label indication, with similar 1-year mortality rates compared to on-label use, suggesting that TAVR may be a possible ...

Neurological events with TAVI and surgical valve replacement in intermediate-risk patients

May 18, 2017
Patients at intermediate risk for surgery have lower risk of early neurological complications including stroke with transcatheter aortic valve implantation (TAVI) than with surgical aortic valve replacement, showed results ...

Transcatheter aortic valve implantation shows promise in patients with severe aortic stenosis

April 10, 2012
German researchers report success with transcatheter aortic valve implantation (TAVI) in patients with low-flow, low-gradient aortic stenosis—a special form of aortic stenosis that is difficult to treat. Results published ...

Researchers find transcatheter aortic valve replacement better for patients with severe aortic stenosis

April 4, 2016
Aortic stenosis (AS), the narrowing of the aortic valve opening which restricts blood flow to the aorta, afflicts nearly 1.5 million people in the United States, with approximately 500,000 of them suffering severe aortic ...

Three SNPs linked to aortic stenosis in older adults

July 6, 2012
(HealthDay) -- Three single nucleotide polymorphisms (SNPs) are associated with aortic stenosis involving tricuspid aortic valves in older patients, according to a study published in the July 1 issue of The American Journal ...

Family history doubles aortic stenosis risk

September 1, 2013
The risk of aortic stenosis doubles when a first degree relative had the disease, according to research presented at ESC Congress 2013 today by Dr. Mattis F. Ranthe from Denmark. The study of 4.2 million people from Danish ...

Recommended for you

New model suggests cuffless, non-invasive blood pressure monitoring possible using pulse waves

October 16, 2018
A large team of researchers from several institutions in China and the U.S. has developed a model that suggests it should be possible to create a cuffless, non-invasive blood pressure monitor based on measuring pulse waves. ...

Why heart contractions are weaker in those with hypertrophic cardiomyopathy

October 16, 2018
When a young athlete suddenly dies of a heart attack, chances are high that they suffer from familial hypertrophic cardiomyopathy (HCM). Itis the most common genetic heart disease in the US and affects an estimated 1 in 500 ...

Novel genetic study sheds new light on risk of heart attack

October 12, 2018
Loss of a protein that regulates mitochondrial function can greatly increase the risk of myocardial infarction (heart attack), Vanderbilt scientists reported Oct. 3 in the journal eLife.

Researchers say ritual for orthodox Jewish men may offer heart benefits

October 11, 2018
A pilot study led by researchers at the University of Cincinnati (UC) College of Medicine suggests Jewish men who practice wearing tefillin, which involves the tight wrapping of an arm with leather banding as part of daily ...

Markers of dairy fat consumption linked to lower risk of type two diabetes

October 10, 2018
Higher levels of biomarkers of dairy fat consumption are associated with a lower risk of developing type 2 diabetes, according to new research published today in PLOS Medicine. The study, in more than 60,000 adults, was undertaken ...

Seed oils are best for LDL cholesterol

October 9, 2018
If you want to lower your low-density lipoprotein cholesterol, called LDL or, colloquially, "bad cholesterol," the research is clear about one thing: You should exchange saturated fats with unsaturated fat. If you want to ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.