Cherokee Nation American Indian Tribe showing it is possible to eliminate hepatitis C

August 9, 2017, World Hepatitis Alliance
Electron micrographs of hepatitis C virus purified from cell culture. Scale bar is 50 nanometers. Credit: Center for the Study of Hepatitis C, The Rockefeller University.

The Cherokee Nation American Indian population is aiming to eliminate hepatitis C virus (HCV) among its tribal citizens, where already almost half have been screened for the virus and around one quarter of those estimated to be infected have already been cured. The tribe will present its progress at the World Indigenous People's Conference on Viral Hepatitis in Anchorage, Alaska (August 8-9).

Hepatitis C is a viral infection which can often remain symptomless for years. Left unchecked, it can cause extensive liver damage, including cirrhosis and ultimately liver cancer and death. Some 71 million people worldwide are thought to be infected, with at least 3 million of those in the USA. Sources of infection include injecting drug use past or present; blood transfusions that took place before 1991 when the virus could not be screened; other unsafe procedures such as unsafe tattooing in which equipment is not properly sterilised; and mother-to-child transmission.

"Various factors have combined to make elimination of C possible," explains Dr. Jorge Mera, Head of Infectious Diseases at Cherokee Nation, headquartered in Tahlequah, OK, USA. "The development of new directly acting antiviral drugs (DAAs) has made hepatitis C treatment much more successful and with fewer side effects. Alongside this, in 2015 the US Centers for Disease Control and Prevention (CDC) offered their support telling us they wanted us to aim for elimination. In collaboration with the University of Oklahoma, the Oklahoma State Health Department and the CDC, we started our HCV elimination program in August of 2015. This was possible through Gilead, one of the leading manufacturers of DAAs, who also donated $1.5 million through its Gilead Foundation to help with screening kits and research."

Although there are more than 350,000 Cherokee Nation tribal citizens worldwide about 130,000 live in northeastern Oklahoma, USA, within the tribe's boundary. Rather than screen just the 'baby-boomer' generation now aged in their 50s, Dr Mera and his team are screening all people aged 20-69 years within the tribe's boundary, some 80,000 people. "Because Cherokee Nation citizens, under a treaty right with the United States Government have access to medical care, tracking them and screening them is slightly easier than might be so for other US populations," explains Dr Mera.

The Indian Health Service (IHS), is an operating division within the US Department of Health and Human Services (HHS) and is responsible for providing direct medical and public health services to members of federally-recognised Native American Tribes and Alaska Native people, including the Cherokee Nation.

IHS helps fund costs and the Cherokee Nation operates one central hospital (W.W. Hastings Hospital) and eight rural centers spread throughout the tribe's jurisdiction for easy access to tribal patients. Dr Mera has worked with them all to provide training and support to help roll out the screening and treatment. Using a program called Extended Community Health Outcomes (ECHO), each health center was trained using teleconferencing and is also able to regularly connect to Dr Mera and other team members centrally to present their cases.

"Anyone entering our health centers who is in this screening age range is offered a test, and almost everyone will say yes. For the 10% or so that say no, we will continue to offer screening whenever they next visit," explains Dr Mera. "However, not everyone is coming to the doctor, of course. So we had the idea of also screening in our dental clinics, to catch our patients in all areas of health care that they might be accessing. Patients who agree to be tested will receive the result then and there and those who test positive will be referred to the hepatitis C clinical provider on the same day in most cases."

In the case of mothers with hepatitis C, if they are unsure when they became infected, then a test is automatically offered to any of her children who could have been infected during the pregnancy. Another crucial screening point is emergency care, when patients come in to the urgent care or the emergency room and have a signed informed consent they will be tested for HCV unless they opt out. Some 70% of newly diagnosed cases are now coming through this route.

Although it was thought that the hepatitis C prevalence in Cherokee Nation could be as high as 6%, more recent epidemiological studies have placed this estimate at 3.4%, similar to the general population across Oklahoma. This means that of the 80,000 citizens to be screened, some 2,800 would be expected to test positive for hepatitis C. However, only 70% of these would be expected to have what is termed 'active' or 'chronic' infection, with the other 30% of cases having self-cleared their infection.

Thus, Dr Mera's team believes that between 1800 and 2000 Cherokee Nation citizens will require treatment for active infection. As of August 2017, just 2 years into the program, huge progress has been made. Around 46,000 people have been screened, 1076 have tested positive (antibodies) of which 760 are chronically infected requiring treatment; 605 patients had begun treatment (with the other 155 awaiting tests or to begin treatment), with 400 already completed and cured. The actual numbers cured are thought to be higher as some patients do not return to take the test required to confirm they are cured. Of those testing positive, around 60% are male and 40% female.

Of course, the battle against hepatitis C in Cherokee Nation is not only about testing and treatment, but also education and awareness. "We are trying to raise awareness among our citizens to prevent further cases," explains Dr Mera. "New treatments have few or no side effects and treatment is completed in just 12 weeks in most cases." Regarding new infections, he adds: "As well as the ongoing dangers of injecting drug use, another problem we may have is that much of the tattooing in Cherokee Nation does not always take place in state-licensed facilities, and it could be a contributor."

He is also hopeful that the scale up of opioid substitution programs in Oklahoma state could have an impact, although needle exchanges remain illegal in the state—something Dr Mera believes must change to help drive down rates of hepatitis and HIV transmitted through this route.

As the elimination project moves forward, cases of hepatitis C may become harder to find. "We will apply for further agency grant funding to help train community health workers to test people who may never visit the doctor or dentist and educate our tribal citizens about why this elimination project is essential. This is similar to the way Navajo Nation American Indian tribe trained their community health workers to test and deliver care for HIV in their population."

"Through Cherokee Nation's successful partnership with the CDC and the state of Oklahoma, and dedicated work by our epidemiologist and health employees, it has drastically cut hepatitis C rates in our tribal population. We hope this blueprint of proactive screening and treatment can be replicated by other tribal health care systems nationwide, and even globally," said Cherokee Nation Principal Chief Bill John Baker. "Hepatitis C does not have to be the death sentence for Indigenous populations that it has historically been."

"This is an inspirational initiative by a population that has been deeply impacted by hepatitis C," says Raquel Peck, Chief Executive of the World Hepatitis Alliance, London, UK. "Cherokee Nation is showing that with political will, financial support and engagement of the community, it is possible for them, and indeed other populations worldwide, to eliminate hepatitis C as a public threat."

Explore further: New research shows indigenous peoples are much more likely to be infected by hepatitis B and/or C

Related Stories

New research shows indigenous peoples are much more likely to be infected by hepatitis B and/or C

August 9, 2017
A new meta-analysis of global hepatitis data—presented at this year's World Indigenous Peoples' Conference on Viral Hepatitis in Anchorage, Alaska, USA (8-9 August)—shows that Indigenous Peoples are up to 10 times more ...

Cherokee nation sues retailers, distributors over opioid crisis

April 24, 2017
(HealthDay)—A lawsuit has been filed by an Indian nation against six of the top drug distributors and pharmacies in the United States for harm done by prescription pain medications.

World Hepatitis Day sets the stage for the elimination of viral hepatitis

July 28, 2017
Today, World Hepatitis Day, marks the first time that the global health community has come together to officially begin moving towards the elimination of viral hepatitis by 2030.

Hepatitis C nearly triples in US in 5 years

May 11, 2017
The number of hepatitis C infections have nearly tripled in the United States in the last five years, particularly among people in their 20s, researchers said Thursday.

Around 9 million Europeans are affected by chronic hepatitis B or C

July 26, 2017
An estimated 4.7 million Europeans are living with chronic hepatitis B and almost 4 million (3.9) with chronic hepatitis C infection. However, large numbers of them are not even aware of their infection as they have not yet ...

Cases of hepatitis B and C hit 325 million: WHO

April 21, 2017
An estimated 325 million people are living with hepatitis B or C and few are aware of their condition, with death tolls from the viruses rising, the UN said Friday.

Recommended for you

Study ends debate over role of steroids in treating septic shock

January 19, 2018
The results from the largest ever study of septic shock could improve treatment for critically ill patients and save health systems worldwide hundreds of millions of dollars each year.

New approach could help curtail hospitalizations due to influenza infection

January 18, 2018
More than 700,000 Americans were hospitalized due to illnesses associated with the seasonal flu during the 2014-15 flu season, according to federal estimates. A radical new approach to vaccine development at UCLA may help ...

Flu may be spread just by breathing, new study shows; coughing and sneezing not required

January 18, 2018
It is easier to spread the influenza virus (flu) than previously thought, according to a new University of Maryland-led study released today. People commonly believe that they can catch the flu by exposure to droplets from ...

Zika virus damages placenta, which may explain malformed babies

January 18, 2018
Though the Zika virus is widely known for a recent outbreak that caused children to be born with microencephaly, or having a small head, and other malformations, scientists have struggled to explain how the virus affects ...

Certain flu virus mutations may compensate for fitness costs of other mutations

January 18, 2018
Seasonal flu viruses continually undergo mutations that help them evade the human immune system, but some of these mutations can reduce a virus's potency. According to new research published in PLOS Pathogens, certain mutations ...

Study reveals how MRSA infection compromises lymphatic function

January 17, 2018
Infections of the skin or other soft tissues with the hard-to-treat MRSA (methicillin-resistant Staphylococcus aureus) bacteria appear to permanently compromise the lymphatic system, which is crucial to immune system function. ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.