Myricetin potentially protective against photodamage of skin

August 24, 2017

(HealthDay)—Myricetin protects cells from photodamage via the IκB/NFκB signaling pathway, according to a study published online Aug. 17 in the Journal of Cosmetic Dermatology.

Jing Xie, M.D., from Shangdong University in Jinan, and Yanyan Zheng, M.D., from the Wenzhou People's Hospital—both in China, examined the effect of myricetin on human keratinocyte cell line (HaCaT) cells. The authors performed a cell viability assay and measured (ROS).

The researchers found that, as determined by the cell viability assay, ultraviolet (UV)-induced keratinocyte death was attenuated by myricetin in a dose-dependent manner. Myricetin pretreatment also reduced the UV-induced ROS levels. Real-time and Western blot showed that myricetin suppressed the upregulation of COX2 induced by UV in keratinocyte. In signal transduction studies, myricetin was confirmed to attenuate COX2 upregulation induced by UV via suppression of IκB/NFκB pathways.

"These results showed that antioxidant property of myricetin can effectively attenuate UV-caused cell damage and suppress the expression of COX2 through the IκB/NFκB signaling pathways," the authors write.

Explore further: MicroRNA controls growth in highly aggressive B-cell lymphomas

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

MicroRNA controls growth in highly aggressive B-cell lymphomas

March 31, 2016
A recent study by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine showed that a microRNA called miR-181a dampens signals from the cancer-driving NFκB protein pathway ...

Curcumin cuts acetaminophen-induced hepatotoxicity in mice

January 23, 2016
(HealthDay)—Curcumin can attenuate acetaminophen-induced mitochondrial alterations in the livers of mice, according to an experimental study published online Jan. 15 in the Journal of Pharmacy and Pharmacology.

TXNIP blocks autophagic flux, causes alpha-synuclein accumulation

August 2, 2017
(HealthDay)—Thioredoxin-interacting protein (TXNIP) blocks autophagic flux and induces expression of α-synuclein accumulation via inhibition of ATP13A2, according to a study published online July 29 in CNS Neuroscience ...

GeroScope—a computer method to model cellular molecular pathways for drug development

December 7, 2016
Russian scientists from MIPT, in collaboration with Insilico Medicine Inc., were commissioned by the Center for Biogerontology and Regenerative Medicine to develop the GeroScope algorithm to identify geroprotectors—substances ...

Milk thistle extract stops lung cancer in mice

November 15, 2011
Tissue with wound-like conditions allows tumors to grow and spread. In mouse lung cancer cells, treatment with silibinin, a major component of milk thistle, removed the molecular billboards that signal these wound-like conditions ...

In vitro effects of topical neuromodulatory medication on orofacial tissue

March 12, 2015
Today at the 93rd General Session and Exhibition of the International Association for Dental Research, researcher M.J. Al-Musawi, Newcastle University, Newcastle upon Tyne, UK, will present a study titled "In Vitro Effects ...

Recommended for you

Building better tiny kidneys to test drugs and help people avoid dialysis

February 16, 2018
A free online kidney atlas built by USC researchers empowers stem cell scientists everywhere to generate more human-like tiny kidneys for testing new drugs and creating renal replacement therapies.

Expanding Hepatitis C testing to all adults is cost-effective and improves outcomes

February 16, 2018
According to a new study, screening all adults for hepatitis C (HCV) is a cost-effective way to improve clinical outcomes of HCV and identify more infected people compared to current recommendations. Using a simulation model, ...

Study suggests expanded range for emerging tick-borne disease

February 16, 2018
Human cases of Borrelia miyamotoi, a tick-borne infection with some similarities to Lyme disease, were discovered in the eastern United States less than a decade ago. Now new research led by the Yale School of Public Health ...

Flu shot only 36 percent effective, making bad year worse (Update)

February 15, 2018
The flu vaccine is doing a poor job protecting older Americans and others against the bug that's causing most illnesses.

IFN-mediated immunity to influenza A virus infection influenced by RIPK3 protein

February 15, 2018
Each year, influenza kills half a million people globally with the elderly and very young most often the victims. In fact, the Centers for Disease Control and Prevention reported 37 children have died in the United States ...

A new class of drug to treat herpes simplex virus-1 infection

February 14, 2018
For patients with the herpes simplex-1 virus (HSV-1), there are just a handful of drugs available to treat the painful condition that can affect the eyes, mouth and genitals.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.