Biomarkers can predict rapid drop in renal function in T2DM

September 11, 2017

(HealthDay)—Plasma biomarkers that may improve the prediction of rapid decline in renal function in type 2 diabetes have been identified, according to a study published online Aug. 29 in Diabetes Care.

Kirsten E. Peters, Ph.D., from the University of Western Australia, and colleagues measured baseline biomarkers in 345 community-based patients from the Fremantle Diabetes Study Phase II. Clinical predictors of rapid estimated (eGFR) decline trajectory defined by semiparametric group-based modeling were determined.

The researchers found in an eGFR trajectory analysis that 10.1 percent of participants were rapid decliners, with a mean decrease of 2.9 mL/min/1.73 m²/year. Plasma apolipoprotein (apo) A-IV (apoA4), CD5 antigen-like (CD5L), and complement C1q subcomponent subunit B (C1QB) independently predicted rapid decline after adjustment for clinical predictors (odds ratios, 2.4, 0.52, and 2.41, respectively), and they improved model performance and fit, discrimination (area under the curve, 0.75 to 0.82), and reclassification (net reclassification index, 0.76; integrated discrimination improvement, 6.3 percent). Together with insulin-like growth factor binding protein 3 (IBP3), these biomarkers contributed to improved model performance in predicting other indices of rapid eGFR .

"The current study has identified novel plasma biomarkers (apoA4, CD5L, C1QB, and IBP3) that may improve the prediction of in independently of recognized clinical risk factors in type 2 diabetes," the authors write.

Several authors are employees of Proteomics International. Proteomics International and the University of Western Australia are owners of a patent relating to the biomarkers described in the study, and several authors are named inventors on the patent.

Explore further: Tryptophan may be marker for diabetic nephropathy

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Tryptophan may be marker for diabetic nephropathy

June 29, 2017
(HealthDay)—For patients with diabetes and chronic kidney disease (CKD), a lower level of tryptophan (Trp) is associated with rapid decline in estimated glomerular filtration rate (eGFR), according to a study published ...

Decline in eGFR mainly linear in type 1 diabetes

September 22, 2016
(HealthDay)—For patients with type 1 diabetes, the decline of estimated glomerular filtration rate (eGFR) is mainly linear, according to a study published online Sept. 19 in Diabetes Care.

Clinical validation results confirm PromarkerD can predict diabetic kidney disease better than any current measure

June 13, 2017
Proteomics International Laboratories Ltd. has announced results from the clinical validation study showing that its PromarkerD blood test can predict the onset of diabetic kidney disease (DKD) better than any current measure.

Metabolites linked to renal decline, time to ESRD in T1DM

January 19, 2017
(HealthDay)—Serum levels of seven modified metabolites are associated with renal function decline and time to end-stage renal disease (ESRD) among patients with type 1 diabetes (T1D), according to a study published online ...

Visceral/subcutaneous fat ratio predicts CVD in T2DM

July 21, 2017
(HealthDay)—For patients with type 2 diabetes, the ratio of visceral fat area (VFA) to subcutaneous fat area (SFA) (V/S ratio) is predictive of cardiovascular disease (CVD), according to a study published online July 7 ...

NT-proBNP improves heart failure prediction in T2DM

July 18, 2017
(HealthDay)—For patients with type 2 diabetes, N-terminal pro-B-type natriuretic peptide (NT-proBNP) improves prediction of heart failure, according to a study published online July 6 in Diabetes Care.

Recommended for you

Scientists reverse diabetes in a mouse model using modified blood stem cells

November 15, 2017
Researchers at Boston Children's Hospital have successfully reversed type 1 diabetes in a mouse model by infusing blood stem cells pre-treated to produce more of a protein called PD-L1, which is deficient in mice (and people) ...

Pregnancy-related conditions taken together leave moms—and dads—at risk

November 14, 2017
Research has already shown that women who develop either diabetes or high blood pressure during pregnancy are at risk of getting type 2 diabetes, high blood pressure or heart disease years later. Now, a new study from a team ...

Study reveals how a very low calorie diet can reverse type 2 diabetes

November 9, 2017
In a new study, a Yale-led research team uncovers how a very low calorie diet can rapidly reverse type 2 diabetes in animal models. If confirmed in people, the insight provides potential new drug targets for treating this ...

Targeting a microRNA shows potential to enhance effectiveness of diabetes drugs

November 7, 2017
Over the past 15 years, University of Alabama at Birmingham endocrinologist Anath Shalev, M.D., has unraveled a crucial biological pathway that malfunctions in diabetes.

Researchers link Western diet to vascular damage and prediabetes

October 31, 2017
Could short-term exposure to the average American diet increase one's risk for developing diabetes and cardiovascular disease? According to a recent study funded by the American Heart Association (AHA), researchers from New ...

Researchers design synthetic beta cells to secrete insulin in response to high blood sugar

October 30, 2017
Treating type 1 diabetes and some cases of type 2 diabetes has long required painful and frequent insulin injections or a mechanical insulin pump for insulin infusion. But researchers from the University of North Carolina ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.