Type 2 diabetes is a reversible condition

September 13, 2017
Credit: CC0 Public Domain

A body of research putting people with Type 2 diabetes on a low calorie diet has confirmed the underlying causes of the condition and established that it is reversible.

Professor Roy Taylor at Newcastle University, UK has spent almost four decades studying the condition and will present an overview of his findings at the European Association For The Study Of Diabetes (EASD 2017) in Lisbon.

In the talk he will be highlighting how his research has revealed that for people with Type 2 diabetes:

  • Excess calories leads to excess fat in the liver
  • As a result, the liver responds poorly to and produces too much glucose
  • Excess fat in the liver is passed on to the pancreas, causing the insulin producing cells to fail
  • Losing less than 1 gram of fat from the pancreas through diet can re-start the normal production of insulin, reversing Type 2 diabetes
  • This reversal of diabetes remains possible for at least 10 years after the onset of the condition

"I think the real importance of this work is for the patients themselves," Professor Taylor says. "Many have described to me how embarking on the low calorie diet has been the only option to prevent what they thought - or had been told - was an inevitable decline into further medication and further ill health because of their diabetes. By studying the underlying mechanisms we have been able to demonstrate the simplicity of type 2 diabetes."

Get rid of the fat and reverse Type 2 diabetes

The body of research by Professor Roy Taylor now confirms his Twin Cycle Hypothesis - that Type 2 diabetes is caused by excess fat actually within both liver and pancreas.

This causes the liver to respond poorly to insulin. As insulin controls the normal process of making glucose, the liver then produces too much glucose. Simultaneously, excess fat in the liver increases the normal process of export of fat to all tissues. In the pancreas, this excess fat causes the insulin producing cells to fail.

The Counterpoint study which was published in 2011, confirmed that if excess food intake was sharply decreased through a very low calorie diet, all these abnormal factors would be reversed.

The study showed a profound fall in liver fat content resulting in normalisation of hepatic insulin sensitivity within 7 days of starting a very in people with type 2 diabetes. Fasting plasma glucose became normal in 7 days. Over 8 weeks, the raised pancreas fat content fell and normal first phase insulin secretion became re-established, with normal plasma glucose control.

Keep the weight off and keep the diabetes at bay

"The good news for people with Type 2 diabetes is that our work shows that even if you have had the condition for 10 years, you are likely to be able to reverse it by moving that all important tiny amount of fat out of the pancreas. At present, this can only be done through substantial ", Professor Taylor adds.

The Counterbalance study published in 2016, demonstrated that Type 2 diabetes remains reversible for up to 10 years in most people, and also that the normal metabolism persists long term, as long as the person doesn't regain the weight.

Professor Taylor explained the science behind the mechanisms: "Work in the lab has shown that the excess fat in the insulin producing cell causes loss of specialised function. The cells go into a survival mode, merely existing and not contributing to whole body wellbeing. Removal of the allows resumption of the specialised function of producing insulin. The observations of the clinical studies can now be fully explained."

He added: "Surprisingly, it was observed that the diet devised as an experimental tool was actually liked by research participants. It was associated with no hunger and no tiredness in most people, but with rapidly increased wellbeing. The 'One, Two' approach used in the Counterbalance study was a defined two phase programme. The Phase 1 is the period of weight loss - calorie restriction without additional exercise. A carefully planned transition period leads to Phase 2 - long term supported weight maintenance by modest calorie restriction with increased daily physical activity."

This approach consistently brings about 15kg of weight loss on average.

After the details were posted on the Newcastle University, UK website, this has been applied clinically and people who were highly motivated have reported that they have reversed their type 2 diabetes and continued to have normal glucose levels (normoglycaemic) over years.

A further study in general practice, the Diabetes Remission Clinical Trial (DiRECT) funded by Diabetes UK is now underway to determine the applicability of this general approach to routine Primary Care practice with findings due before the end of the year.

Patients or GPs who would like more information about the diet that reverses Type 2 see the Magnetic Resonance Centre website.

Explore further: Type 2 diabetes reversed by losing fat from pancreas

Related Stories

Type 2 diabetes reversed by losing fat from pancreas

December 1, 2015
A team from Newcastle University, UK, has shown that Type 2 diabetes is caused by fat accumulating in the pancreas—and that losing less than one gram of that fat through weight loss reverses the diabetes.

Intermittent fasting could help tackle diabetes – here's the science

August 21, 2017
Intermittent fasting is currently all the rage. But don't be fooled: it's much more than just the latest fad. Recent studies of this kind of fasting – with restricted eating part of the time, but not all of the time – ...

Diet reverses type 2 diabetes

June 24, 2011
(Medical Xpress) -- A Newcastle University team has discovered that Type 2 diabetes can be reversed by an extreme low calorie diet alone. Affecting two and half million people in the UK – and on the increase – Type ...

Reverse your diabetes—and you can stay diabetes-free long-term

March 21, 2016
A new study from Newcastle University has shown that people who reverse their diabetes and then keep their weight down remain free of diabetes.

Fasting plasma glucose and insulin are determinants of dietary weight loss success

June 12, 2017
Researchers from the University of Copenhagen, together with colleagues from the University of Colorado, Tufts University, Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBER OBN) ...

Fasting-mimicking diet may reverse diabetes

February 23, 2017
A diet designed to imitate the effects of fasting appears to reverse diabetes by reprogramming cells, a new USC-led study shows.

Recommended for you

Study identifies blood vessel as a therapeutic target for diabetes

September 14, 2017
Blood vessels have an often overlooked role of regulating the transfer of nutrients from the blood to organs in the body. In a new Yale-led study, researchers have identified a role of a secreted protein, apelin, in regulating ...

Drug for type 2 diabetes provides significant benefits to type 1 diabetic patients

September 14, 2017
A majority of patients with Type 1 diabetes who were treated with dapagliflozin, a Type 2 diabetes medicine, had a significant decline in their blood sugar levels, according to a new study published in The Lancet Diabetes ...

Could swine flu be linked to type 1 diabetes?

September 14, 2017
(HealthDay)—Young people who've been infected with the H1N1 swine flu virus may be at increased risk for type 1 diabetes, a new study suggests.

Epigenetic 'fingerprint' identifies diabetes risk

September 14, 2017
Deakin researchers have identified an epigenetic marker that predicts risk of type 2 diabetes in women with gestational diabetes.

Time to dial back on diabetes treatment in older patients? Study finds 11 percent are overtreated

September 14, 2017
Anyone with diabetes who takes blood sugar medication knows their doctor prescribed it to help them. After all, the long-term effects of elevated blood sugar can harm everything from the heart and kidneys to the eyes and ...

Novel way to present pancreatic proteins increases the sensitivity of type 1 diabetes tests

September 13, 2017
Researchers from the Johns Hopkins University School of Medicine, Stanford University and the University of Florida report the development of a novel antibody detection technology that holds promise for improving the accuracy ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.