Sleep and Alzheimer's disease connection

October 17, 2017 by From Mayo Clinic News Network, Mayo Clinic News Network
PET scan of a human brain with Alzheimer's disease. Credit: public domain

How often do you get a good night's sleep? Centers for Disease Control and Prevention guidelines recommend adults get an average of at least seven hours of sleep a night. Dr. Ronald Petersen, a Mayo Clinic neurologist, says prolonged lack of sleep could raise your risk of many health issues, including Alzheimer's disease.

Getting a good night's is important. Lack of sleep increases your risk of , weight gain and even heart disease. Now you might be able to add Alzheimer's disease to that list.

"There were several studies on the impact of sleep, on developing cognitive impairment and maybe even Alzheimer's disease, showing that disrupted sleep, , various disorders of breathing can be deleterious with regard to cognitive function, and maybe even the development of Alzheimer's disease," says Petersen.

Petersen says the theory behind the sleep-Alzheimer's link has to do with a substance called amyloid.

"Amyloid, one of the proteins that's thought to cause the disease, may build up in the brain normally throughout life, but, at night, when we're sleeping, particularly when we get into deep sleep, the protein gets cleared from the brain."

So if you don't get into , amyloid may not be cleared from your brain.

"It's conceivable that impaired sleep over many years may actually enhance the buildup of these abnormal proteins in the brain."

Sleep hygiene is very, very important.

"If you do have a disorder of breathing in sleep, get that addressed and treated earlier rather than later."

Explore further: Sleep problems may be early sign of Alzheimer's

55 shares

Related Stories

Sleep problems may be early sign of Alzheimer's

July 5, 2017
Poor sleep may be a sign that people who are otherwise healthy may be more at risk of developing Alzheimer's disease later in life than people who do not have sleep problems, according to a study published in the July 5, ...

How much sleep do you really need?

July 20, 2017
(HealthDay)—Health initiatives typically center on diet and fitness. But the American Academy of Sleep Medicine and the Sleep Research Society state that getting enough sleep is just as important as eating right and exercising.

Can poor sleep boost odds for Alzheimer's?

July 18, 2017
(HealthDay)— Breathing problems during sleep may signal an increased risk for Alzheimer's disease, a trio of studies suggests.

Lack of REM sleep may lead to higher risk for dementia

August 23, 2017
Spending less time in REM (rapid eye movement) sleep and taking longer to enter REM sleep are separately associated with a higher risk of developing dementia.

Sleep, Alzheimer's link explained

July 10, 2017
A good night's sleep refreshes body and mind, but a poor night's sleep can do just the opposite. A study from Washington University School of Medicine in St. Louis, Radboud University Medical Centre in the Netherlands, and ...

AAIC: Alzheimer biomarkers up with sleep disordered breathing

July 18, 2017
(HealthDay)—Biological changes in the brain may underlie a relationship between sleep disordered breathing (SDB) and Alzheimer's disease, according to new research. A trio of studies on the matter were scheduled for presentation ...

Recommended for you

Many cases of dementia may arise from non-inherited DNA 'spelling mistakes'

October 15, 2018
Only a small proportion of cases of dementia are thought to be inherited—the cause of the vast majority is unknown. Now, in a study published today in the journal Nature Communications, a team of scientists led by researchers ...

Scientists create new map of brain region linked to Alzheimer's disease

October 8, 2018
Curing some of the most vexing diseases first requires navigating the world's most complex structure—the human brain. So, USC scientists have created the most detailed atlas yet of the brain's memory bank.

Previously unknown genetic aberrations found to be associated with Alzheimer's progression

October 8, 2018
In a large-scale analysis of RNA from postmortem human brain tissue, researchers at the Icahn School of Medicine at Mount Sinai and Columbia University have identified specific RNA splicing events associated with Alzheimer's ...

Periodontal disease bacteria may kick-start Alzheimer's

October 4, 2018
Long-term exposure to periodontal disease bacteria causes inflammation and degeneration of brain neurons in mice that is similar to the effects of Alzheimer's disease in humans, according to a new study from researchers at ...

AI could predict cognitive decline leading to Alzheimer's disease in the next five years

October 4, 2018
A team of scientists has successfully trained a new artificial intelligence (AI) algorithm to make accurate predictions regarding cognitive decline leading to Alzheimer's disease.

Medical-records study links dementia-related brain changes to hospital stays for critical illness

September 27, 2018
Researchers at Johns Hopkins report that a novel analysis of more than a thousand patients adds to evidence that hospitalization, critical illness and major infection may diminish brain structures that are most commonly affected ...

1 comment

Adjust slider to filter visible comments by rank

Display comments: newest first

drsteenblock
not rated yet Oct 17, 2017
More important is a lack of oxygen for more than a few minutes while sleeping. This causes the production of amyloid in those areas that develop hypoxia while sleeping and the amyloid triggers the phosphorylation ot Tau which then causes the destruction of the neurons in the locus coerulus and then upwards into the entire brain. David Steenblock,DO www stemcellmd dot org

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.