Overall survival up for melanoma brain metastases

Overall survival up for melanoma brain metastases

(HealthDay)—Overall survival (OS) for patients with melanoma brain metastases (MBM) has improved significantly since 2000, according to a study published online Oct. 12 in Cancer.

Sarah Sloot, M.D., from Groningen University Medical Center in the Netherlands, and colleagues identified 610 patients with unresectable American Joint Committee on Cancer stage III/IV melanoma who received first-line systemic therapy at Moffitt Cancer Center between 2000 and 2012.

The researchers found that 243 of the 610 patients were diagnosed with MBM. Patients with MBM were younger and had a lower frequency of regional metastasis. There were no significant differences with regard to sex, BRAF status, or therapeutic class. The risk of de novo MBM was similar among patients treated with chemotherapy, biochemotherapy, BRAF-targeted therapy, ipilimumab, and anti- protein 1/programmed death-ligand 1 regimens. With MBM the median OS was significantly shorter when determined from the time of first regional/distant metastasis but not when determined from the time of first systemic therapy. From the time of MBM diagnosis, the median OS was 7.5 months for patients diagnosed from 2000 to 2008; 8.5 months with diagnoses from 2009 to 2010, and 22.7 months for those diagnosed from 2011 to the time of last follow-up.

"Brain metastases remain a common source of systemic treatment failure," the authors write. "The OS for with MBM has improved significantly. Further research into MBM prevention is needed."

Several authors disclosed financial ties to the pharmaceutical industry, and one has patents pending for an ipilimumab biomarker and a programmed cell death protein 1 biomarker.

Explore further

Immune checkpoint inhibitor endocrine dysfunction explored

More information: Abstract
Full Text (subscription or payment may be required)
Journal information: Cancer

Copyright © 2017 HealthDay. All rights reserved.

Citation: Overall survival up for melanoma brain metastases (2017, October 18) retrieved 27 September 2022 from https://medicalxpress.com/news/2017-10-survival-melanoma-brain-metastases.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors