ASN: PPIs associated with increased risk of kidney disease

November 6, 2017

(HealthDay)—Proton pump inhibitor (PPI) users have an increased risk of chronic kidney disease (CKD) or end-stage renal disease (ESRD), according to a review presented at the annual meeting of the American Society of Nephrology, being held Oct. 31 to Nov. 5 in New Orleans.

Karn Wijarnpreecha, M.D., from Bassett Medical Center in Cooperstown, New York, and colleagues conducted a literature review to identify all studies through March 2017 that evaluated the risk of CKD or ESRD among PPI users versus non-PPI users. Five studies (three cohort studies and two case-control studies with 536,902 participants) were included in the meta-analysis.

The researchers found that PPI users had a significantly increased risk of CKD or ESRD versus non-PPI users (pooled relative risk, 1.33). Funnel plots showed no publication bias for included studies.

"This study demonstrated an increased risk of CKD or ESRD among PPI users. Whether this association is causal requires further investigations," the authors write.

Explore further: Reflux medications linked to chronic kidney disease and kidney failure

More information: Abstract
More Information

Related Stories

Reflux medications linked to chronic kidney disease and kidney failure

November 5, 2017
A recent analysis has linked certain medications commonly used to treat heartburn, acid reflux, and ulcers with the development of kidney disease. The findings will be presented at ASN Kidney Week 2017 October 31-November ...

Kidney damage seen in most patients with long-lasting T1D

October 30, 2017
(HealthDay)—Most patients with type 1 diabetes (T1D) of long duration have some degree of kidney disease, according to a study published online Oct. 4 in Diabetes Care.

Metabolites linked to renal decline, time to ESRD in T1DM

January 19, 2017
(HealthDay)—Serum levels of seven modified metabolites are associated with renal function decline and time to end-stage renal disease (ESRD) among patients with type 1 diabetes (T1D), according to a study published online ...

Post-RFA mortality up for ESRD patients who receive dialysis

March 20, 2017
(HealthDay)—For patients with end-stage renal disease (ESRD), receipt of hemodialysis (HD) is associated with increased mortality after radiofrequency ablation (RFA) for hepatocellular carcinoma, according to a study published ...

No increase in acute kidney injury risk for SGLT2 users

August 24, 2017
(HealthDay)—The risk of acute kidney injury (AKI) is not increased for new sodium-glucose cotransporter-2 (SGLT2) inhibitor users, according to a study published online Aug. 21 in Diabetes Care.

Review finds CABG bests PCI in end-stage renal disease

May 5, 2016
(HealthDay)—For patients with end-stage renal disease (ESRD) referred for coronary revascularization, coronary artery bypass grafting (CABG) is associated with a small decrease in long-term mortality compared with percutaneous ...

Recommended for you

Past encounters with the flu shape vaccine response

February 20, 2018
New research on why the influenza vaccine was only modestly effective in recent years shows that immune history with the flu influences a person's response to the vaccine.

Building better tiny kidneys to test drugs and help people avoid dialysis

February 16, 2018
A free online kidney atlas built by USC researchers empowers stem cell scientists everywhere to generate more human-like tiny kidneys for testing new drugs and creating renal replacement therapies.

Study suggests expanded range for emerging tick-borne disease

February 16, 2018
Human cases of Borrelia miyamotoi, a tick-borne infection with some similarities to Lyme disease, were discovered in the eastern United States less than a decade ago. Now new research led by the Yale School of Public Health ...

Expanding Hepatitis C testing to all adults is cost-effective and improves outcomes

February 16, 2018
According to a new study, screening all adults for hepatitis C (HCV) is a cost-effective way to improve clinical outcomes of HCV and identify more infected people compared to current recommendations. Using a simulation model, ...

Flu shot only 36 percent effective, making bad year worse (Update)

February 15, 2018
The flu vaccine is doing a poor job protecting older Americans and others against the bug that's causing most illnesses.

IFN-mediated immunity to influenza A virus infection influenced by RIPK3 protein

February 15, 2018
Each year, influenza kills half a million people globally with the elderly and very young most often the victims. In fact, the Centers for Disease Control and Prevention reported 37 children have died in the United States ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.