ASN: PPIs associated with increased risk of kidney disease

November 6, 2017

(HealthDay)—Proton pump inhibitor (PPI) users have an increased risk of chronic kidney disease (CKD) or end-stage renal disease (ESRD), according to a review presented at the annual meeting of the American Society of Nephrology, being held Oct. 31 to Nov. 5 in New Orleans.

Karn Wijarnpreecha, M.D., from Bassett Medical Center in Cooperstown, New York, and colleagues conducted a literature review to identify all studies through March 2017 that evaluated the risk of CKD or ESRD among PPI users versus non-PPI users. Five studies (three cohort studies and two case-control studies with 536,902 participants) were included in the meta-analysis.

The researchers found that PPI users had a significantly increased risk of CKD or ESRD versus non-PPI users (pooled relative risk, 1.33). Funnel plots showed no publication bias for included studies.

"This study demonstrated an increased risk of CKD or ESRD among PPI users. Whether this association is causal requires further investigations," the authors write.

Explore further: Reflux medications linked to chronic kidney disease and kidney failure

More information: Abstract
More Information

Related Stories

Reflux medications linked to chronic kidney disease and kidney failure

November 5, 2017
A recent analysis has linked certain medications commonly used to treat heartburn, acid reflux, and ulcers with the development of kidney disease. The findings will be presented at ASN Kidney Week 2017 October 31-November ...

Kidney damage seen in most patients with long-lasting T1D

October 30, 2017
(HealthDay)—Most patients with type 1 diabetes (T1D) of long duration have some degree of kidney disease, according to a study published online Oct. 4 in Diabetes Care.

Metabolites linked to renal decline, time to ESRD in T1DM

January 19, 2017
(HealthDay)—Serum levels of seven modified metabolites are associated with renal function decline and time to end-stage renal disease (ESRD) among patients with type 1 diabetes (T1D), according to a study published online ...

Post-RFA mortality up for ESRD patients who receive dialysis

March 20, 2017
(HealthDay)—For patients with end-stage renal disease (ESRD), receipt of hemodialysis (HD) is associated with increased mortality after radiofrequency ablation (RFA) for hepatocellular carcinoma, according to a study published ...

No increase in acute kidney injury risk for SGLT2 users

August 24, 2017
(HealthDay)—The risk of acute kidney injury (AKI) is not increased for new sodium-glucose cotransporter-2 (SGLT2) inhibitor users, according to a study published online Aug. 21 in Diabetes Care.

Review finds CABG bests PCI in end-stage renal disease

May 5, 2016
(HealthDay)—For patients with end-stage renal disease (ESRD) referred for coronary revascularization, coronary artery bypass grafting (CABG) is associated with a small decrease in long-term mortality compared with percutaneous ...

Recommended for you

Anti-malaria drug shows promise as Zika virus treatment

November 17, 2017
A new collaborative study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) and UC San Diego School of Medicine has found that a medication used to prevent and treat malaria may also be effective ...

Decrease in sunshine, increase in Rickets

November 17, 2017
A University of Toronto student and professor have teamed up to discover that Britain's increasing cloudiness during the summer could be an important reason for the mysterious increase in Rickets among British children over ...

Scientists identify biomarkers that indicate likelihood of survival in infected patients

November 17, 2017
Scientists have identified a set of biomarkers that indicate which patients infected with the Ebola virus are most at risk of dying from the disease.

Research team unlocks secrets of Ebola

November 16, 2017
In a comprehensive and complex molecular study of blood samples from Ebola patients in Sierra Leone, published today (Nov. 16, 2017) in Cell Host and Microbe, a scientific team led by the University of Wisconsin-Madison has ...

Study raises possibility of naturally acquired immunity against Zika virus

November 16, 2017
Birth defects in babies born infected with Zika virus remain a major health concern. Now, scientists suggest the possibility that some women in high-risk Zika regions may already be protected and not know it.

A structural clue to attacking malaria's 'Achilles heel'

November 16, 2017
Researchers from The Scripps Research Institute (TSRI) and PATH's Malaria Vaccine Initiative (MVI) have shed light on how the human immune system recognizes the malaria parasite though investigation of antibodies generated ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.