Maternal GDM tied to child's cardiometabolic profile

November 22, 2017

(HealthDay)—Teenage offspring of mothers with gestational diabetes mellitus (GDM) have increased adiposity and an adverse cardiometabolic profile, according to a study published online Oct. 16 in Diabetes Care.

Louise G. Grunnet, Ph.D., from Rigshospitalet in Copenhagen, Denmark, and colleagues compared body composition and associated cardiometabolic traits among 561 9- to 16-year-old of with GDM and 597 control offspring.

The researchers found that offspring of mothers with GDM exhibited higher weight, body mass index (BMI), waist-to-hip ratio (WHR), systolic blood pressure, and resting heart rate, and lower height, after adjustment for age and sex. Higher total and abdominal fat percentages and lower muscle mass percentages were seen for offspring of mothers with GDM; after correction for offspring BMI, these differences disappeared. Higher fasting plasma glucose, insulin, C-peptide, homeostatic model assessment of insulin resistance (HOMA-IR), and plasma triglyceride levels were seen for offspring of mothers with GDM; they also had reduced fasting plasma high-density lipoprotein cholesterol levels. Compared with control offspring, female offspring of mothers with GDM had earlier onset of puberty. After adjustment for maternal prepregnancy BMI, offspring of mothers with GDM had significantly higher BMI, WHR, fasting glucose, and HOMA-IR; glucose and HOMA-IR remained elevated after correction for maternal and offspring BMI.

"Adolescent offspring of women with GDM show increased adiposity, an adverse cardiometabolic profile, and earlier onset of puberty among girls," the authors write.

One author disclosed financial ties to Novo Nordisk.

Explore further: Maternal hyperglycemia ups offspring cardiometabolic risk

More information: Abstract/Full Text (subscription or payment may be required)

Related Stories

Maternal hyperglycemia ups offspring cardiometabolic risk

March 20, 2017
(HealthDay)—Maternal hyperglycemia during pregnancy is associated with increased risk of abnormal glucose tolerance, obesity, and increased blood pressure (BP) in offspring, independent of maternal obesity, according to ...

Maternal hyperglycemia not linked to obesity in offspring

June 29, 2015
(HealthDay)—Maternal hyperglycemia seems not to be a risk factor for obesity in offspring aged 5 to 7 years after adjustment for maternal body mass index (BMI), according to a study published online June 19 in Diabetes ...

Long-term effect of gestational diabetes treatment uncertain

December 9, 2014
(HealthDay)—The effects of treatment of mild gestational diabetes mellitus (GDM) on long-term child health are unclear, according to research published online Nov. 20 in Diabetes Care.

Maternal low protein diet promotes diabetic phenotypes in offspring

September 2, 2014
Millions of people throughout the world are affected by diabetes. In particular, the rise in the incidence of type 2 diabetes is associated with global increases in obesity and changes in diet. There is also a genetic component ...

Cardiometabolic risk, HOMA-IR up with increasing BMI in young

September 27, 2017
(HealthDay)—Cardiometabolic risk and homeostatic model assessment (HOMA) of insulin resistance (IR) increase with increasing body mass index (BMI) categories among children, and cardiorespiratory fitness (CRF) may attenuate ...

Maternal uncontrolled asthma ups risk of asthma in offspring

July 17, 2017
(HealthDay)—Children whose mothers have uncontrolled asthma during pregnancy are at increased risk of developing the disease at a young age, according to a study published online July 13 in the Journal of Allergy and Clinical ...

Recommended for you

A novel insulin accelerant

October 17, 2018
Insulin levels rise after eating a meal, signaling uptake of circulating glucose by skeletal muscle. In individuals with diabetes this process is often impaired—a condition known as insulin resistance.

Fat tissue may play a crucial role in the progression of diabetes, challenging long established notions

October 12, 2018
A new study by Australian researchers, out today, is challenging what we know about the causes of diabetes. The new research points to fat tissue as a source of disease, and widens our understanding beyond the traditional ...

Does breastfeeding hormone protect against type 2 diabetes?

October 12, 2018
(HealthDay)—The hormone prolactin—most commonly associated with breastfeeding—may play a role in reducing the risk of type 2 diabetes, a new study suggests.

Planned intermittent fasting may help reverse type 2 diabetes, suggest doctors

October 10, 2018
Planned intermittent fasting may help to reverse type 2 diabetes, suggest doctors writing in the journal BMJ Case Reports after three patients in their care, who did this, were able to cut out the need for insulin treatment ...

Markers of dairy fat consumption linked to lower risk of type two diabetes

October 10, 2018
Higher levels of biomarkers of dairy fat consumption are associated with a lower risk of developing type 2 diabetes, according to new research published today in PLOS Medicine. The study, in more than 60,000 adults, was undertaken ...

New discovery restores insulin cell function in type 2 diabetes

October 8, 2018
By blocking a protein, VDAC1, in the insulin-producing beta cells, it is possible to restore their normal function in case of type 2 diabetes. In preclinical experiments, the researchers behind a new study have also shown ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.