Maternal GDM tied to child's cardiometabolic profile

Maternal GDM tied to child's cardiometabolic profile

(HealthDay)—Teenage offspring of mothers with gestational diabetes mellitus (GDM) have increased adiposity and an adverse cardiometabolic profile, according to a study published online Oct. 16 in Diabetes Care.

Louise G. Grunnet, Ph.D., from Rigshospitalet in Copenhagen, Denmark, and colleagues compared body composition and associated cardiometabolic traits among 561 9- to 16-year-old of with GDM and 597 control offspring.

The researchers found that offspring of mothers with GDM exhibited higher weight, body mass index (BMI), waist-to-hip ratio (WHR), systolic blood pressure, and resting heart rate, and lower height, after adjustment for age and sex. Higher total and abdominal fat percentages and lower muscle mass percentages were seen for offspring of mothers with GDM; after correction for offspring BMI, these differences disappeared. Higher fasting plasma glucose, insulin, C-peptide, homeostatic model assessment of insulin resistance (HOMA-IR), and plasma triglyceride levels were seen for offspring of mothers with GDM; they also had reduced fasting plasma high-density lipoprotein cholesterol levels. Compared with control offspring, female offspring of mothers with GDM had earlier onset of puberty. After adjustment for maternal prepregnancy BMI, offspring of mothers with GDM had significantly higher BMI, WHR, fasting glucose, and HOMA-IR; glucose and HOMA-IR remained elevated after correction for maternal and offspring BMI.

"Adolescent offspring of women with GDM show increased adiposity, an adverse cardiometabolic profile, and earlier onset of puberty among girls," the authors write.

One author disclosed financial ties to Novo Nordisk.


Explore further

Maternal hyperglycemia ups offspring cardiometabolic risk

More information: Abstract/Full Text (subscription or payment may be required)
Journal information: Diabetes Care

Copyright © 2017 HealthDay. All rights reserved.

Citation: Maternal GDM tied to child's cardiometabolic profile (2017, November 22) retrieved 22 September 2019 from https://medicalxpress.com/news/2017-11-maternal-gdm-tied-child-cardiometabolic.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
0 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more