Older people with bowel disease receive older medicines

November 13, 2017, Karolinska Institutet

Inflammatory bowel disease is common amongst older people and there are big differences in the choice of treatment for different age groups. Patients over the age of 60 often receive cortisone drugs instead of more modern medicines that target the immune system. This according to a large registry study from Karolinska Institutet in Sweden published in Gastroenterology.

Inflammatory bowel disease includes Crohn's disease, which can affect the whole intestine, and , which affects the colon and rectum. Symptoms include blood in the stool, diarrhoea and . Treatment consists of and surgery to remove the damaged part of the intestines. The most common age of onset is 20-30, and previous studies have claimed that it is uncommon for the disease to debut over the age of 60 and when it does, it is less severe.

"We therefore sought to ascertain the incidence of in older age groups and if there is any difference in how they are treated and how they use the healthcare services," says Åsa Hallqvist Everhov, researcher at Karolinska Institutet's Department of Clinical Research and Education, Stockholm South General (Söder) Hospital (KI SÖS) and at the same hospital.

The study included all new cases of inflammatory bowel disease in Sweden between 2006 and 2014. The resulting group of just under 28,000 patients was split into three sub-groups depending on year of onset: childhood (<18), adult (18-59) and old adult (?60). Data were sourced from the National Board of Health and Welfare's patients and prescribed drugs registers, subject to a maximum monitoring period of nine years. The researchers compared the patients' healthcare consumption with that of a matched group selected from the general population.

Just over one fifth of the participants were over 60. The study also shows that this group consumed more healthcare than the two younger groups and more than their matched peers without inflammatory disease. They were also operated on more often and sooner after disease onset, often already within the first year.

"It's common, in other words, for the disease to onset after the age of 60 and we found no evidence that when it does, the disease progress is milder," says Dr Hallqvist Everhov.

One important finding was the big difference in medication between the age groups. More younger patients received modern immunomodulating drugs and TNF inhibitors, whereas older cortisone drugs were more commonly given to the older patients.

"We don't know the reason for this, but it could be due either to under-prescription to older sufferers or to prudent choice, since the newer drugs carry certain risks and side-effects," continues Dr. Hallqvist Everhov. "Older patients often already have other potent drugs."

The researchers plan to examine the causes of the treatment discrepancies in a new study.

Explore further: Inflammatory bowel disease in childhood associated with increased risk of cancer

More information: Åsa H. Everhov et al, Incidence and Treatment of Patients Diagnosed With Inflammatory Bowel Diseases at 60 Years or Older in Sweden, Gastroenterology (2017). DOI: 10.1053/j.gastro.2017.10.034

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