Scientists identify new marker of arthritis in mice

November 22, 2017, Wiley

Researchers have discovered a new marker of arthritis in mice that can be used non-invasively to both identify joints with established arthritis and to predict subsequent joint swelling. The finding is published in Arthritis & Rheumatology.

The investigators note that imaging tests with the marker—called Ratiometric thrombin-Activatable Cell Penetrating Peptide—might help clinicians monitor the development and progression of arthritis and other .

"This new imaging tool should allow researchers to localize very early events in to enable translational advances," said senior author Dr. Maripat Corr, of the University of California San Diego. Image: topically applied Ratiometric thrombin-Activatable Cell Penetrating Peptide to a cryosection from a paw of a mouse injected with K/BxN serum demonstrating areas of cleavage in the warmer colors (red/orange).

Explore further: Maintaining sufficient vitamin D levels may help to prevent rheumatoid arthritis

More information: Beth Friedman et al, A thrombin receptor - derived imaging agent detects subclinical arthritis in mice, Arthritis & Rheumatology (2017). DOI: 10.1002/art.40316

Related Stories

Maintaining sufficient vitamin D levels may help to prevent rheumatoid arthritis

November 20, 2017
Maintaining sufficient vitamin D levels may help to prevent the onset of inflammatory diseases like rheumatoid arthritis, research led by the University of Birmingham has discovered.

Bioactive lipids and rheumatoid arthritis

November 2, 2017
Sphingolipids – long-chain fatty acid molecules found in cell membranes – are broken down by sphingomyelinase enzymes into bioactive products such as ceramide. Growing evidence suggests roles for sphingolipid metabolites ...

Old World monkeys could be key to a new, powerful rheumatoid arthritis therapy

November 16, 2017
In the quest for a new and more effective treatment for rheumatoid arthritis, researchers from the Keck School of Medicine of USC looked to a primate that mostly roams the land in Asia, the Middle East and Africa. It was ...

New psoriatic arthritis treatment guideline presented at the 2017 ACR/ARHP Annual Meeting

November 5, 2017
Authors of the new American College of Rheumatology (ACR) / National Psoriasis Foundation (NPF) treatment guideline for psoriatic arthritis (PsA) will present their draft recommendations during a session at the 2017 ACR/ARHP ...

Rheumatoid arthritis linked to an increased risk of COPD

October 19, 2017
New research suggests that rheumatoid arthritis may increase the risk of developing chronic obstructive pulmonary disease (COPD). The findings, which appear in Arthritis Care & Research, indicate that greater vigilance may ...

Arthritis in the hands more common than you might think, study says

May 17, 2017
Arthritis in the hands is more common than you might think. Nearly 1 in 2 women and 1 in 4 men will develop the condition in their lifetime, according to a new study.

Recommended for you

How the brain plays a role in rheumatoid arthritis inflammation

June 18, 2018
In patients with chronic inflammatory conditions, such as rheumatoid arthritis, there has been limited understanding of how this inflammation affects the brain.

New 3-D imaging analysis technique could lead to improved arthritis treatment

June 18, 2018
An algorithm to monitor the joints of patients with arthritis, which could change the way that the severity of the condition is assessed, has been developed by a team of engineers, physicians and radiologists led by the University ...

Joint resolution: A link between Huntington's disease and rheumatoid arthritis

May 15, 2018
Using new analytic tools, researchers at University of California San Diego School of Medicine and the Icahn School of Medicine at Mount Sinai have decoded the epigenetic landscape for rheumatoid arthritis (RA), a common ...

Get off the golf cart if you have knee osteoarthritis

April 28, 2018
From presidents to retirees, more than 17 million people over the age of 50 golf regularly. Knee osteoarthritis, which causes swelling, pain and difficulty moving the joint, is one of the leading causes of disability in this ...

How environmental pollutants and genetics work together in rheumatoid arthritis

April 19, 2018
It has been known for more than three decades that individuals with a particular version of a gene—human leukocyte antigen (HLA)—have an increased risk for rheumatoid arthritis.

The bugs in your gut could make you weak in the knees

April 19, 2018
Bacteria in the gut, known as the gut microbiome, could be the culprit behind arthritis and joint pain that plagues people who are obese, according to a new study published today in JCI Insight.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.