Doctors develop new way to use MRI to predict pregnancy complications

December 6, 2017 by Elaine Schmidt, University of California, Los Angeles
A technique developed at UCLA measures how much blood enters the placenta and reaches the developing baby in the womb, expanding doctors’ ability to determine the health of the placenta. Credit: University of California, Los Angeles

UCLA scientists have developed a new way to use magnetic resonance imaging, or MRI, to scan the placenta. The noninvasive approach offers valuable insights into how the mother's blood enters the placenta and sustains the fetus with oxygen and nutrients during early pregnancy. The technique breaks new ground because most previous studies on this subject occurred in the laboratory after childbirth.

The placenta is a temporary organ that joins a pregnant woman to her baby through the umbilical cord. Few methods exist for safely and accurately studying the placenta in . Ultrasound indirectly measures uterine blood flow, but it is not very effective at predicting pregnancy complications. Another procedure, chorionic villus sampling, can be used to biopsy the placenta, but the test is invasive and can increase the risk of miscarriage and infection.

The researchers used MRI to track water molecules in the arterial blood of 34 women in their second trimester of pregnancy. The new technique allowed the team to measure how much blood entered the placenta and reached the developing baby in the womb, expanding doctors' ability to accurately determine the health of the placenta.

Using MRI enables doctors to measure blood flow to the and distinguish between normal and abnormal placental function. The information allows them to predict and prevent complications later in pregnancy before symptoms or testing occur. Common complications include premature birth, placental stroke, and gestational hypertension, and preeclampsia.

The study was published in the Journal of Magnetic Resonance Imaging.

Explore further: Genetic finding may allow doctors to predict newborn health during pregnancy

More information: Xingfeng Shao et al. Measuring human placental blood flow with multidelay 3D GRASE pseudocontinuous arterial spin labeling at 3T, Journal of Magnetic Resonance Imaging (2017). DOI: 10.1002/jmri.25893

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