Lipid-linked genetic risk tied to abdominal aortic aneurysm

December 5, 2017

(HealthDay)—Lipid-associated genetic risk correlates with the risk of abdominal aortic aneurysm (AAA), according to a study published online Nov. 29 in JAMA Cardiology.

Seamus C. Harrison, Ph.D., from Addenbrooke's Hospital in Cambridge, U.K., and colleagues examined the correlation between lipid-associated single-nucleotide polymorphisms (SNPs) and AAA risk in an analysis involving up to 4,914 cases and 48,002 controls. Genetic risk scores were constructed and tested for their association with AAA using conventional and mendelian randomization (MR) and data from international genome-wide association studies.

The researchers found that a one-standard deviation (SD) genetic elevation of (LDL-C) correlated with elevated AAA risk (odds ratio, 1.66). A one-SD increase for high-density lipoprotein cholesterol (HDL-C) correlated with a reduction in AAA risk (odds ratio, 0.67). A one-SD increase in triglycerides correlated with an increase in AAA risk (odds ratio, 1.69). The association for each lipid fraction with AAA risk was largely unchanged in multivariable MR analysis and MR-Egger and weighted median MR methods. There were correlations for the LDL-C reducing-allele of rs12916 in HMGCR with AAA risk (odds ratio, 0.93) and for the HDL-C-raising allele of rs3764261 in CETP with lower AAA risk (odds ratio, 0.89).

"The MR analyses in this study lend support to the hypothesis that lipids play an important role in the etiology of AAA," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Explore further: ApoB levels more closely tied to reduced CVD events than LDL

More information: Abstract/Full Text

Related Stories

ApoB levels more closely tied to reduced CVD events than LDL

August 29, 2017
(HealthDay)—Clinical benefit of reduced low-density lipoprotein cholesterol (LDL-C) levels may depend on the corresponding reduction in apolipoprotein B (apoB)-containing lipoprotein particles, according to a study published ...

Exposure to LDL-C-lowering genetic variants ups T2DM risk

October 7, 2016
(HealthDay)—Low-density lipoprotein cholesterol (LDL-C)-lowering genetic variants are associated with increased risk of type 2 diabetes, according to a meta-analysis published in the Oct. 4 issue of the Journal of the American ...

Retinal emboli linked to cardiac risk factors, kidney disease

August 31, 2017
(HealthDay)—Retinal emboli are associated with conventional cardiovascular risk factors, stroke, and chronic kidney disease, according to a study published online Aug. 24 in JAMA Ophthalmology.

No causal link between plasma lipids, diabetic retinopathy

October 11, 2017
(HealthDay)—There does not seem to be a causal relationship between plasma lipids and diabetic retinopathy (DR), according to a study published in the September issue of Diabetes.

Inflammatory biomarkers may impact risk of schizophrenia

November 3, 2017
(HealthDay)—Specific inflammatory biomarkers may impact the risk of developing schizophrenia, with a protective effect noted for C-reactive protein (CRP) and a risk-increasing effect for soluble interleukin-6 receptor (sIL-6R), ...

Genetic vitamin K1 levels linked to heart disease

April 18, 2016
(HealthDay)—Genetically determined vitamin K1 is associated with coronary artery disease (CAD) and myocardial infarction (MI), according to a study published online April 8 in the Journal of Thrombosis and Haemostasis.

Recommended for you

Scientists rewrite our understanding of how arteries mend

December 13, 2017
Scientists from The University of Manchester have discovered how the severity of trauma to arterial blood vessels governs how the body repairs itself.

Deadly heart rhythm halted by noninvasive radiation therapy

December 13, 2017
Radiation therapy often is used to treat cancer patients. Now, doctors at Washington University School of Medicine in St. Louis have shown that radiation therapy—aimed directly at the heart—can be used to treat patients ...

Ultra-thin tissue samples could help to understand and treat heart disease

December 12, 2017
A new method for preparing ultra-thin slices of heart tissue in the lab could help scientists to study how cells behave inside a beating heart.

Research reveals how diabetes in pregnancy affects baby's heart

December 12, 2017
Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have discovered how high glucose levels—whether caused by diabetes or other factors—keep heart cells from maturing ...

Young diabetics could have seven times higher risk for sudden cardiac death

December 12, 2017
Young diabetics could have seven times more risk of dying from sudden cardiac arrest than their peers who don't have diabetes, according to new research.

Blood flow–sensing protein protects against atherosclerosis in mice

December 12, 2017
UCLA scientists have found that a protein known as NOTCH1 helps ward off inflammation in the walls of blood vessels, preventing atherosclerosis—the narrowing and hardening of arteries that can cause heart attacks and strokes. ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.