Fractional exhaled nitric oxide moderately accurate to diagnose asthma
Zhen Wang, Ph.D., from the Mayo Clinic in Rochester, Minn., and colleagues conducted a systematic literature review to identify studies that evaluated FeNO diagnostic accuracy in patients ≥5 years with suspected asthma.
The researchers included 43 studies with a total of 13,747 patients. Using FeNO cutoffs of <20, 20 to 29, 30 to 39, and 40 or more parts per billion, FeNO testing yielded sensitivities of 0.8, 0.69, 0.53, and 0.41, respectively, and specificities of 0.64, 0.78, 0.85, and 0.93, respectively, in adults. By comparison, using FeNO cutoffs of <20 and 20 to 29 parts per billion in children yielded sensitivities of 0.78 and 0.61, respectively, and specificities of 0.79 and 0.89, respectively. In corticosteroid-naive asthma patients, children, and nonsmokers, the diagnostic accuracy was modestly better than in the overall population.
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