Herbal products may compromise prescription drugs and cause serious side effects

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An analysis of published studies and reports indicates that a number of herbal products may affect the properties of prescription drugs, leading to alterations in the drugs' effectiveness as well as potentially dangerous side effects.

The British Journal of Clinical Pharmacology analysis included 49 case reports and two observational studies with 15 cases of . The majority of patients were diagnosed with cardiovascular diseases, cancer, and kidney transplants and were receiving mostly warfarin, alkylating agents, and cyclosporine, respectively.

Investigators noted that patients taking warfarin and/or statins for the treatment of cardiovascular complications reported significant interactions after taking including sage, flaxseed, St. John's wort, cranberry, goji juice, green tea, and chamomilla.

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More information: Charles Awortwe et al, Critical Evaluation of Causality Assessment of Herb-Drug Interactions in Patients, British Journal of Clinical Pharmacology (2018). DOI: 10.1111/bcp.13490
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