Prenatal PPI, H2 blocker use linked to asthma risk in child

January 12, 2018

(HealthDay)—Prenatal, maternal, acid-suppressive drug use is associated with an increased risk of childhood asthma, according to a review published online Jan. 11 in Pediatrics.

Tianwen Lai, M.D., Ph.D., from Zhejiang University in China, and colleagues conducted a systematic literature review to identify eight population-based studies that assessed acid-suppressive drug use during pregnancy and the risk of childhood asthma in offspring.

In pooled analysis, the researchers found that acid-suppressive drug use in pregnancy was associated with an increased risk of asthma in childhood (relative risk, 1.45). Among users, the overall risk of asthma in childhood increased (relative risk, 1.34). Similarly, the risk increased in histamine-2 receptor antagonist users (relative risk, 1.57).

"The evidence suggests that prenatal, maternal, acid-suppressive drug use is associated with an increased risk of ," the authors write. "This information may help clinicians and parents to use caution when deciding whether to take acid-suppressing drugs during because of the risk of asthma in offspring."

Explore further: Maternal uncontrolled asthma ups risk of asthma in offspring

More information: Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Related Stories

Maternal uncontrolled asthma ups risk of asthma in offspring

July 17, 2017
(HealthDay)—Children whose mothers have uncontrolled asthma during pregnancy are at increased risk of developing the disease at a young age, according to a study published online July 13 in the Journal of Allergy and Clinical ...

Maternal gestational weight tied to offspring's asthma risk

July 25, 2014
(HealthDay)—Maternal obesity in pregnancy (MOP) and high maternal gestational weight gain (GWG) are associated with an elevated risk of childhood asthma, according to a review published online July 21 in Pediatrics.

Researchers ID microbiome genes tied to asthma

November 22, 2017
(HealthDay)—Functional genes in the upper airway microbiome may be tied to childhood asthma, according to a study published Nov. 20 in Allergy.

Consuming sugary drinks during pregnancy may increase asthma risk in mid-childhood

December 8, 2017
Children between the ages of 7 and 9 may be at greater risk for developing asthma if they consumed high amounts of fructose in early childhood or their mothers drank a lot of sugar-sweetened beverages while pregnant, according ...

Fish-oil fatty acids in pregnancy cut wheeze, asthma risk in child

December 29, 2016
(HealthDay)—For women in the third trimester of pregnancy, supplementation with n-3 long-chain polyunsaturated fatty acids (LCPUFAs) is associated with a reduction in the risk of persistent wheeze and asthma in offspring, ...

Acid suppressive medication may increase risk of pneumonia

December 20, 2010
Using acid suppressive medications, such as proton pump inhibitors and histamine2 receptor antagonists, may increase the risk of developing pneumonia, states an article in CMAJ (Canadian Medical Association Journal).

Recommended for you

Fatty acids can slow down an overheated immune system

September 21, 2018
Sometimes, the immune system mistakenly attacks the body's healthy tissue by responding to infections that do not exist. This causes chronic inflammation and leads to diseases including lupus (SLE), and this is what happens ...

Patient-centered visual aid helps physicians discuss risks, treatments with parents

September 21, 2018
A series of illustrations and charts designed as decision aids for parents of children with minor head injuries helped them communicate with emergency medicine physicians and make informed decisions about their child's care, ...

Study shows surprise low-level ozone impact on asthma patients

September 21, 2018
A new study led by UNC School of Medicine researchers indicates that ozone has a greater impact on asthma patients than previously thought. The study, published in the Journal of Allergy and Clinical Immunology, recruited ...

Fish-rich diets may boost babies' brain development

September 20, 2018
Women could enhance the development of their unborn child's eyesight and brain function by regularly eating fatty fish during pregnancy. This is the suggestion from a small-scale study led by Kirsi Laitinen of the University ...

Understanding epilepsy in pediatric tumors

September 20, 2018
Pediatric brain tumors are characterized by frequent complications due to intractable epilepsy compared to adult brain tumors. However, the genetic cause of refractory epilepsy in pediatric brain cancer has not been elucidated ...

3-D-printed tracheal splints used in groundbreaking pediatric surgery

September 19, 2018
Children's Healthcare of Atlanta has performed Georgia's first-ever procedure to place 3-D-printed tracheal splints in a pediatric patient. A cross-functional team of Children's surgeons used three custom-made splints, which ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.