Risk-based lung cancer screening may save more lives than current USPSTF guidelines

January 2, 2018, American College of Physicians

Lung cancer screening based on individual risk has the potential to save more lives than current recommendations by the U.S. Preventive Services Task Force (USPSTF). The findings are published in Annals of Internal Medicine.

The USPSTF recommends annual lung cancer with low-dose computed tomography (CT) for persons aged 55 to 80 years who currently smoke or quit within the past 15 years and have at least a 30-pack-year history of cigarette smoking. These criteria may miss smokers at high risk for lung cancer who would have been selected for CT screening by individual risk calculators that more specifically account for demographic, clinical, and smoking characteristics.

Researchers from the National Cancer Institute used data from the National Health Interview Survey to compare USPSTF eligibility criteria with individualized, risk-based eligibility and estimate the effect of eligibility on lung cancer deaths preventable by screening since 2005. They found that using the Lung Cancer Risk Assessment Tool would draw in high-risk moderate smokers with a history of 20 to 29 pack-years who are currently ineligible for screening using USPSTF criteria.

This approach could have prevented over 5,000 more deaths in 2015 than using the USPSTF screening criteria. Because of the U.S. population changes related to smoking between 2010 and 2015, adhering to the USPSTF criteria led to fewer ever-smokers being eligible for CT screening and fewer deaths being averted by screening.

Explore further: Risk-based CT screening may reduce deaths from lung cancer

More information: Annals of Internal Medicine (2018). http://annals.org/aim/article/doi/10.7326/M17-2067

Related Stories

Risk-based CT screening may reduce deaths from lung cancer

January 1, 2018
Compared to National Lung Screening Trial criteria, targeting screening those at highest risk from lung cancer mortality using a risk prediction tool may improve efficiency in terms of greater reduction in mortality from ...

Lung cancer screening rates remain very low among current and former smokers

February 2, 2017
Lung cancer screening rates remained very low and unchanged among eligible populations in 2015, despite recommendations that high risk current and former smokers be screened. The study by American Cancer Society investigators ...

Risks of LDCT LC screenings need to be assessed in 20- to 29-pack-year smokers

October 19, 2015
The potential risks and harms of low-dose CT (LDCT) lung cancer screening in current 20- to 29-pack-year smokers needs to be assessed before recommending LDCT to this group, according to a study published October 19 in the ...

Lung cancer risk model refines decisions to screen

December 2, 2014
A new method for determining lung cancer risk could more efficiently identify individuals for annual screening and catch more cancers early, according to a study published in this week's PLOS Medicine. The study, conducted ...

USPSTF reviews use of ECG for preventing A-fib, CVD events

December 19, 2017
(HealthDay)—The U.S. Preventive Services Task Force (USPSTF) has found that the current evidence is inadequate to assess the benefits and harms of screening with electrocardiogram (ECG) for atrial fibrillation (AF) in older ...

Less inclusive criteria for lung cancer screening would be cost-effective

February 7, 2017
Limiting lung cancer screening to high-risk former smokers may improve cost-effectiveness at a population level, according to a study published in PLOS Medicine. Regular computed tomography (CT) lung cancer screening of current ...

Recommended for you

Scientists discover new method of diagnosing cancer with malaria protein

August 17, 2018
In a spectacular new study, researchers from the University of Copenhagen have discovered a method of diagnosing a broad range of cancers at their early stages by utilising a particular malaria protein that sticks to cancer ...

Researchers find pathways that uncover insight into development of lung cancer

August 17, 2018
Lung cancer is the leading cause of preventable cancer death. A disease of complex origin, lung cancer is usually considered to result from effects of smoking and from multiple genetic variants. One of these genetic components, ...

Developing an on-off switch for breast cancer treatment

August 17, 2018
T-cells play an important role in the body's immune system, and one of their tasks is to find and destroy infection. However, T-cells struggle to identify solid, cancerous tumors in the body. A current cancer therapy is using ...

Pregnant? Eating broccoli sprouts may reduce child's chances of breast cancer later in life

August 16, 2018
Researchers at the University of Alabama at Birmingham have found that a plant-based diet is more effective in preventing breast cancer later in life for the child if the mother consumed broccoli while pregnant. The 2018 ...

Three scientists share $500,000 prize for work on cancer therapy

August 15, 2018
Tumors once considered untreatable have disappeared and people previously given months to live are surviving for decades thanks to new therapies emerging from the work of three scientists chosen to receive a $500,000 medical ...

PARP inhibitor improves progression-free survival in patients with advanced breast cancers

August 15, 2018
In a randomized, Phase III trial led by researchers at The University of Texas MD Anderson Cancer Center, the PARP inhibitor talazoparib extended progression-free survival (PFS) and improved quality-of-life measures over ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.