A new class of drug to treat herpes simplex virus-1 infection

February 14, 2018, University of Illinois at Chicago
Mock-treated mouse eyes at day 3 and day 7 post-infection (left panel), showing worsened symptoms by day 7. In contrast, TFT- and BX795-treated eyes (middle and right panels) remained healthy. Credit: D. Jaishankar et al., Science Translational Medicine (2018)

For patients with the herpes simplex-1 virus (HSV-1), there are just a handful of drugs available to treat the painful condition that can affect the eyes, mouth and genitals.

If patients develop resistance to these drugs, there are even fewer choices left to treat the infection, which lasts for life.

Researchers at the University of Illinois at Chicago have now identified a small drug molecule that can clear the HSV-1 infection in the of the cornea—the clear outer layer of the eyeball—and works completely differently than the currently-available drugs, making it a promising potential option for patients who have developed resistance.

The researchers believe the drug could be equally effective in treating HSV-1 in the mouth and HSV-2 —which primarily affects the genitals—and possibly even other viral infections like HIV. The findings are reported in the journal Science Translational Medicine.

HSV-1 is one of the most common human pathogens, affecting between 50 percent and 90 percent of people worldwide. HSV-1 primarily infects the mouth and eyes, although genital cases of HSV-1 infection are on the rise. The is transmitted through bodily fluids. It establishes a lifelong infection that leads to sores in affected tissues when active and hides in nerve cells during its latent phase. The infection can be temporarily eliminated in the eye using oral and topical antiviral drugs, but inflammation of the cornea can persist indefinitely, requiring ongoing treatment with steroid-based eye drops. HSV-1 infection is a leading cause of infectious blindness in the United States.

Currently available drugs to treat HSV-1 infection work by preventing the virus from producing the proteins it needs to replicate and are known as nucleoside analogs. Resistance is a significant problem with the ongoing use of nucleoside analogs, which when applied topically to the eye can cause serious side effects including glaucoma.

"We have needed alternative drugs that work on new targets for a very long time because patients who develop resistance to nucleoside analogs have very few good options for treating their infection," said Deepak Shukla, the Marion Schenk Professor of Ophthalmology and professor of microbiology and immunology in the UIC College of Medicine, and corresponding author on the paper. "We have found a molecule that works in a totally novel fashion. Instead of working on the virus, it works in the host cells and helps them to clear the virus."

Shukla and colleagues discovered that a small molecule called BX795, which is sold to labs for use in experiments, helped clear HSV-1 infection in cultured human corneal cells, in donated human corneas, and in the corneas of mice infected with HSV-1.

Description of BX795 as a new antiviral Credit: Tejabhiram Yadavalli, PhD at the University of Illinois at Chicago Department of Ophthalmology and Visual Sciences

The researchers were quite surprised by their finding because BX795 is known as an inhibitor of TBK1, an enzyme involved in innate immunity and neuroinflammation. When TBK1 is suppressed in cells, infection is actually promoted. But when the researchers added higher concentrations of BX795 to cultured human corneal cells infected with HSV-1, the infection was quickly cleared. They had the same result in intact human corneas, and in mice whose eyes had been infected with HSV-1.

"This isn't what we expected," said Tejabhiram Yadavalli, a postdoctoral fellow studying herpes viruses at UIC and a co-author of the paper. "Instead of promoting infection, at higher concentrations, BX795 actually helped cells clear the infection."

Additionally, the concentration of BX795 needed to clear HSV-1 is quite low.

"We saw clearance of the virus at concentrations of BX795 that were five times lower than concentrations of antiviral compounds in available nucleoside analogs," Shukla said.

The researchers also found that BX795 only worked in cells infected with the HSV-1 virus.

"There was no discernable toxicity or negative side effects at therapeutic concentrations in cells that are not infected with the virus," Shukla said.

"Because BX795 targets a common pathway that many viruses use to replicate inside the cell, it could be a new kind of broad-spectrum antiviral that might be used to treat other , including HSV-2, which primarily affects the genitals, and HIV, although we have not yet tested it on viruses other than HSV-1."

"It will be very exciting to see if the study can move to a clinical trial soon," said Alex Agelidis, a graduate student at UIC and co-author on the paper. "Because of BX795's low toxicity, it has a great potential for systemic use as well as topical application."

Explore further: Researchers identify master molecule behind corneal inflammation

More information: D. Jaishankar el al., "An off-target effect of BX795 blocks herpes simplex virus type 1 infection of the eye," Science Translational Medicine (2018). stm.sciencemag.org/lookup/doi/ … scitranslmed.aan5861

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gloria23
1 / 5 (1) Feb 18, 2018
Hello everyone!! I was diagnosed of Genital Herpes Simplex Virus (HSV) in 2015 and I have tried all possible means to get cured, i even visited Some Hospital where they gave me some drugs like Famvir, Zovirax and Valtrex which are very expensive but all to no avail, until i saw a post in a health forum about a herbal doctor from West Africa who prepare herbal medicine to cure all kind of diseases including Herpes Simplex Virus, at first i doubted if it was real but decided to give it a try, when i contact this herbal doctor via his email he sent me a herbal medicine through courier service, when i received this herbal medicine, he gave me step by instructions on how to apply it, when i applied it as instructed i was totally cured of this deadly disease within 12-14 days of usage, if you are suffering of this diseases you can as well Contact this great herbal doctor via his email; dr.osatomeherbalhome@gmail.com or whatsapp no:+2348159921615
gloria23
1 / 5 (1) Feb 26, 2018
Hello everyone!! I was diagnosed of Genital Herpes Simplex Virus (HSV) in 2015 and I have tried all possible means to get cured, i even visited Some Hospital where they gave me some drugs like Famvir, Zovirax and Valtrex which are very expensive but all to no avail, until i saw a post in a health forum about a herbal doctor from West Africa who prepare herbal medicine to cure all kind of diseases including Herpes Simplex Virus, at first i doubted if it was real but decided to give it a try, when i contact this herbal doctor via his email he sent me a herbal medicine through courier service, when i received this herbal medicine, he gave me step by instructions on how to apply it, when i applied it as instructed i was totally cured of this deadly disease within 12-14 days of usage, if you are suffering of this diseases you can as well Contact this great herbal doctor via his email; dr.osatomeherbalhome@gmail.com or whatsapp no:+2348159921615
gloria23
1 / 5 (1) Mar 07, 2018
Thanks to great Dr Osatome that i met on this site. i am Gloria Williams. i was an HPV victim. i had it for over five years i do visit hospital always before. I was just at the point of death with shame after i have lost everything in life even my love one until my close relative direct me to this site to look for great Dr Osatome. It so amazing to see my self back to my feet with every thing i have lost. i am very happy because Dr Osatome did not only cure my sickness but he restructure my life by bringing back my ex and every thing i lost to the course of this sickness(HPV). i do not really know where to start from in appreciating you Dr Osatome . please my people out there do not play with your problem go out and seeks for the help of great Dr Osatome herbal healing, he healed me without future problem or hidden charges. now i am free from HPV and My husband, my joy and happiness are back. please with out a second choice go contact great Dr Osatome for the betterment of your life.
WMorgan
1 / 5 (1) Mar 12, 2018
I am glad with the invention of natural remedy cure for herpes. Sometimes last year I was checking for permanent solution to this offensive infection then I came across a testimony shared by someone who got cured already and I applied through remedyforherpescure@gmail.com. I was called to confirm if I actually needed the cure, I said yes that I really needed the cure so I ordered and it was sent me. I used the remedy for two weeks then after that I was totally relieved of all symptoms. Now I am completely free from HSV11. You can also make your own order through remedyforherpescure@gmail.com if you also want cure too


gloria23
1 / 5 (1) Mar 13, 2018
Hello everyone!! I was diagnosed of Genital Herpes Simplex Virus (HSV) in 2015 and I have tried all possible means to get cured, i even visited Some Hospital where they gave me some drugs like Famvir, Zovirax and Valtrex which are very expensive but all to no avail, until i saw a post in a health forum about a herbal doctor from West Africa who prepare herbal medicine to cure all kind of diseases including Herpes Simplex Virus, at first i doubted if it was real but decided to give it a try, when i contact this herbal doctor via his email he sent me a herbal medicine through courier service, when i received this herbal medicine, he gave me step by instructions on how to apply it, when i applied it as instructed i was totally cured of this deadly disease within 12-14 days of usage, if you are suffering of this diseases you can as well Contact this great herbal doctor via his email; dr.osatomeherbalhome@gmail.com or whatsapp no:+2348159921615
gloria23
1 / 5 (1) Mar 19, 2018
Thanks to great Dr Osatome that i met on this site. i am Gloria Williams. i was an HPV victim. i had it for over five years i do visit hospital always before. I was just at the point of death with shame after i have lost everything in life even my love one until my close relative direct me to this site to look for great Dr Osatome. It so amazing to see my self back to my feet with every thing i have lost. i am very happy because Dr Osatome did not only cure my sickness but he restructure my life by bringing back my ex and every thing i lost to the course of this sickness(HPV). i do not really know where to start from in appreciating you Dr Osatome . please my people out there do not play with your problem go out and seeks for the help of great Dr Osatome herbal healing, he healed me without future problem or hidden charges. now i am free from HPV and My husband, my joy and happiness are back. please with out a second choice go contact great Dr Osatome for the betterment of your life.
Anonym112289
1 / 5 (1) Mar 19, 2018
I was diagnosed with Genital herpes for close to 8 months, my friend Lilian visited me and introduce me to Dr Ose that he can cure me I never believe because I have spend so much money on different doctors she advice me to try him because he cured her too on her Cancer disease. so I mailed him, he welcome me and I complain to him about my illness, he said to me I am in the right place. today Dr Ose cured me with a herbal medicine, all i did was to order for the herbs, he sent it to me through courier delivery services and ask me to drink it for a period of 4 weeks, but before the completion of the 4th week i was totally cured,I'm so happy. thanks you doctor. I share this because I care about you all too because he said, he also said he have herbs for all kind of illness including HIV/AIDS, ASTHMA, CANCER, DIABETIC 1&2, GONORRHEA, BARRENNESS, IMPOTENCE, WOMB DAMAGE, HIGH BLOOD PRESSURE, EPILEPSY,PREGNANCY,Email him now on droseherbalhome@gmail.com or whatsapp him/call on +2348139560075
colemanarnold80
1 / 5 (1) Mar 27, 2018
Hi, I finally understood how spells works. my wife left me due to the fact that i was diagnosed with Herpes Simplex Virus. I was heart broken that she left me for another. I did all i could to get her back but all i did never worked out for me not until my cousin from New Zealand got me informed about this man called Lord Doctor Zakuza that he's very powerful and can be of help to me. I believed and got in touch with the Doctor and i opened up to him everything that i was going through. Could you believe it that i was cured from the Herpes Simplex Virus and my wife came back all within 12 to 16 hours after i contacted the Doctor. Everything happened miraculously just has he told me if only i have faith & believe that it will happen and now my wife is here with me again and am strong & healthy again. All thanks to Lord Doctor Zakuza for his help. Get in touch now for any help whatsoever for i believe that he can help you too. For urgent response, Whats App him via + 1 (631)-857-8413 or
falcaoroland
1 / 5 (1) Mar 28, 2018
Greetings to you all, i am Falcao Roland,i am broadcasting about how Dr Olori saved my life, i was infected with Genital Herpes for A year, my medical Dr told me that there i no total cure and i began to take pill to sustain my self. One day i went to see my medical doctor and i saw a lady who was extremely happy and i asked to know the reason of her happiness and she told me that she was infected with simplex HERPES disease and a herbal doctor called Dr Olori cured her with herbal medicine, i did not believe so i asked my medical doctor to know if she was truly confirmed Herpes positive before, and my medical doctor told me yes that a miracle just happened so i asked her to give me the details of the Dr so i could ask him if he could also cure mine and she gave me Dr Olori Email: droloriherbalcenter@gmail.com I contacted him that very evening and i explained my problem to him and he prepared a medicine and send to me, when i received the medicine he told me how to take it for a peri
LynAnd01
1 / 5 (1) Mar 28, 2018
Herpes Virus cure with the help of natural herbal medication for herpes and Human Papilloma Virus cure do contact Dr Uyi for help and for any other disease [ SICKNESS ] for solution.

Herpes and HPV being Sexually Transmitted Diseases (STDs) can severely restrict one's social and love life. Many people suffering from these conditions choose to remain silent, thus living a life filled completely with loneliness and frustration. But life isn't over yet. You can not only find support with millions of other people with the same condition. I bring to you good news that can get you a permanent cure through real and effective herbal cure. He cured me and could cure you too, contact Dr Uyi via his email: uyiherbalmedicationcenter@gmail.com call or whatsAPP Him with this number: +2348077199766.
Anonym226470
1 / 5 (1) Mar 28, 2018
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petertcholi
1 / 5 (1) Mar 29, 2018
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as you know around the world. there is a cure for herpes and the government kept it
for their own selfish self. my cousine fred was diogonise of herpes virus six years ago
he works for a popular pharmacist in town due to his experience in herbes he was given a very vital role in
the company. not until he had the virus. he met doctor Nze Njoku who supplied herbal stuffs for
the company. he had a one on one conversation with the
herbalist man who assured him that there is cure for the virus. He went to the management
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To his greatest shock he was sacked for beleiving in feltishness
he stayed with the herbal man who truley cured him of the virus. you can reach him via; nzenjokuherbalhome@gmail.com. whatsapp him via +2347032718477
CathyLee
1 / 5 (1) Mar 31, 2018
I am really happy that i have been cured from (HERPES SIMPLEX VIRUS) with the herbal medicine of Dr Ofua Ofure. , i have been suffering from this disease for the past 2 years and 7 mouth without solution until i came across the blog of this doctor who have cure so many people with his herbal medicine, i also choose to give him a chance to help me and my husband, he told me what to do and i kindly did it, and he gave us his herbal medicine and direct me on how to use it, i also follow his instructions for use and he ask us to go for a check up after 2 week and 4days which i did, to my greatest surprise our result came out as negative, and ever since then, we have had no more outbreak and we are healthy, we are really happy that there is someone like this doctor who is ready to help anytime any day. he also render cure to the following diseases below
.DIABETES
.CANCER
.HEPATITIS
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Epilepsypatient
1 / 5 (1) Apr 05, 2018
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Epilepsypatient
1 / 5 (1) Apr 05, 2018
Contact Dr. Patrick IF you are having Pie, cancer, epilepsy and so many other deadly and infections diseases and sickness, with the use of his miracle healing herbs, you will be free from that condition you are totally and this cure last forever. His email is herbalmedicalhome@gmail.com and whatsapp number is +1 (412) 338-3358 contact him and i bet you that you will see goodnews after using his herbal medicine. website is doctorpatrickherbalhome dot webs dot com
Anonym396904
1 / 5 (1) Apr 05, 2018
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Anonym396904
1 / 5 (1) Apr 05, 2018
I was diagnosed of herpes in 2016 and I tried all possible means to get cure but all to no avail until i saw a post in a health forum about a herbal doctor from Africa who prepare herbal medicine to cure all kind of diseases including herpes virus, at first i doubted if it was real but decided to give it a try, when i contact this herbal doctor via his email ozalogboshrine@gmail.com i bought the herpes herbal medicine and received it through UPS COURIER SERVICE within 7 days and used it as prescribed, i was cured permanently of hepatitis b virus within 3 weeks of usage. Thanks to DR ozalogbo herbal medicine,you can as well contact him via his whatsapp number +2348162562992 He got a lot of information to help cure any type disease.......
graceamyton
1 / 5 (1) Apr 05, 2018
Am very glad to share this testimony with everyone for the marvelous work Dr falanshe has done for my life, 6months ago i was diagnosed with hepatitis B and ever since then i have been very unhappy, i was so down broken everyday, until one day when i came across a shocking testimony about how Dr falanshe helping others, i contacted him and he directed me on how to get the med. and after 3weeks of using i was completely cured contact Dr falanshe as he cures other ailment, 1 cancer cure

2 diabetes cure

3 ringing ear

4 herpes cure 5 HIV 6 get your love back

email:drfalanshehealinghome@gmail.com call or whatsapp +2348059836514 please share the good news once you are cured
graceamyton
1 / 5 (1) Apr 05, 2018
Am very glad to share this testimony with everyone for the marvelous work Dr falanshe has done for my life, 6months ago i was diagnosed with hepatitis B and ever since then i have been very unhappy, i was so down broken everyday, until one day when i came across a shocking testimony about how Dr falanshe helping others, i contacted him and he directed me on how to get the med. and after 3weeks of using i was completely cured contact Dr falanshe as he cures other ailment, 1 cancer cure

2 diabetes cure

3 ringing ear

4 herpes cure 5 HIV 6 get your love back

email:drfalanshehealinghome@gmail.com call or whatsapp +2348059836514 please share the good news once you are cured....
Epilepsypatient
1 / 5 (1) Apr 05, 2018
I want to thank God for using great Dr. Patrick to cure me from herpes with his powerful herbs treatment. I am Connie Smith, I am here to tell the world that there is a powerful traditional herbal doctor who is well perfect in curing people from different types of diseases, illness and infection, he is a man who can use his liquid herbal medicines to cure people with thier different states of problem. Here I am today, I am a living testimony, I had herpes for five years now and i have tried so many doctor and tried so many types of treatment, i undergo through many sufferings and shames for five years and finally now, Dr. Patrick has put a smile in my face that will last forever, if not for God for directing me to Dr. Patrick, I would have been a dead woman today, nevertheless all thanks goes to God. I was cured after using the great herbs of Doc Patrick for one month and now I cured from herpes and I have my test result here with me, I ordered for his medicines September 20th last y
Epilepsypatient
1 / 5 (1) Apr 05, 2018
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I pray may the God heal you too as you contact him.
Thanks....
victoria24
1 / 5 (1) Apr 06, 2018
herpes cure from Dr abdul
i'm Mrs victorious Johnston want to share with the world on how God use Dr abdul to heal me and my husband from herpes of 3 years after so many failed attempts from different doctors until i was able to contact Dr abdul. Today my husband and i is free from herpes disease after just few days of administering Dr abdul simple solution.
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victoria24
1 / 5 (1) Apr 06, 2018
hello everyone.my name is hanna from USA. i want you people to help me thank Dr abdul for curing my herpes of 6 years with his herbal solution.I wouldnt have believed if not that i was a victim.He used his herbs to cure me within just 5 days.indeed he is really wonderful and magical with his herbs.
The interesting thing is that he cures not just herpes but all kinds of diseases and sicknesses like cancer,stroke,diabettis,mburns,respiratory,respiratory infection,pulmunary disease,cirrhosis, tubbercolosis,ischemic heart disease,brain tumor,canker sores,cholesterol,heart failure,bad breath,alopecia,bed wetting and other issues.You can reach him via his mail drabdulsolutioncentre@gmail.com or watsapp +2348031519690....Goodluck...
barakn
5 / 5 (1) Apr 09, 2018
Does this article win for the most spam comments ever?
victoria24
not rated yet Apr 09, 2018
hello,i'm victoria johnston from USA.
I want to tell the world and those who knew me with my mental illness that am free through a

simple solution from Dr Abdul.A friend of mine told my family about him and we decided to contact him through his email and give it a try because so many doctors has failed us and behold i was made whole in just few days by this simple Dr Abdul's solution. This is indeed unbeleiveable and am pretty sure that Dr Abdul will solve any health challenge that you might be facing today if you can also give him a try.
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CrystalRobin
not rated yet Apr 09, 2018
Hello Dr Suku is real and he's powerful herbal treatment..After been in pain and sorrow for over 7years it was Dr.SUKU that cured me from Hepatitis B Virus, I got infected with Hepatitis B Disease in 2010 and I have visited several herbalists, spiritualists and pastors for cure me but all was in avail, my world was gradually coming to an end until i saw a post in a health forum about a herbal medicine from Africa who have and herbal medicine to cure all kinds of deadly diseases including HERPES ,WALTER,HIV AIDS, ALS, HPV, MND, Epilepsy, Leukemia, Asthma, Cancer, Ghonorhea,Hepatitis B etc, at first i doubted if it was real but decided to give it a try, when i contact this herbalist via his email, drsukuherbalhome@gmail.com he prepared a herbal medicine portion and sent it to me via DHL Delivery when i received this herbal medicine portion, he gave me step by step instructions on how to apply it, his email: drsukuherbalhome@gmail.com or
Text/Call cell number +1(325) 701-3934
Anonym884230
not rated yet Apr 11, 2018
hello friends,am Wanda Dancy from U S A. God is be really good to me in my life, before people said there is no cure on H.P.V TYPE, but today many people have now believe that there is a cure FOR H.P.V/ IT can be cured through Africans root and herbs, our great doctors have finally found the cure of H.P.V, many have get cured with the help of a great spell caster known as Dr Ose he's the one of the great spell herbal doctor in Africa and he has the cure on this disease H.P.V/TYPE 1 TYPE 2 TYPE 3 AND TYPE 4. TYPE 5, human papilomavirus, genital warts, herpes, syphilis, cancer, hepatitis a b and c. high blood pressures, body disease, diabetics, epilepsy, HIV aids, pregnancy,ALS and many difference kinds of diseases, last month he share is Herbal medicine in some medical hospital and now he is well recognize as one of the best spell caster in Africa, you don't have to be sad any more or share your tears any more on this disease when the cure have already be found. in 2015 the total numbe
crystaljoseph6449
not rated yet Apr 11, 2018
Good day to evryone here. Any body reading this testimony now should help me to rejoice and thank dr tokubo for curing me completely from herpes virus . I was told i have herpes in 2015, i have been taking different kinds of medication still yet no improvement until i saw testimonies of a woman who dr tokubo helped to cure herpes. I was skeptical about contacting him but i also knew the importance of herbal medicine because i have heard about it before that i work perfectly, i made up my mind and contacted him we talked on phone and he prepared the herbs medicine and send the medicine to me through DHL delivery services which i took according to his dosage information. Now I'm so happy I'm cured from Herpes my heart is so filled with joy because my herpes test came out negative, thank you so much Dr Tokubo. If you are reading this and you have Herpes or any kind of disease contact him +2349037990322 or email him at drtokubotemple@gmail.com
Anonym481262
not rated yet Apr 13, 2018
I'm here to testify about what DR. Ehizele did for me. I have been suffering from (GENITAL HERPES VIRUS) disease for the past 3 years and had constant pain and inching, especially in my private part. During the first year, I had faith in God that i would be cured someday.This disease started circulating all over my body and I have been taking treatment from my doctor, few weeks ago I came across a testimony of Rose Smith on the internet testifying about a Man called DR. Ehizele on how he cured her from 7 years HSV 2. And she also gave the email address of this man,ehizeleherbalhome@gmail.com advise anybody to contact him for help on any kind of diseases that he would be of help, so I emailed him telling him about my (HSV 2) he told me not to worry that I was going to be cured!! Well, I never doubted him I have faith he can cure me too,, DR. Ehizele prepared and sent me Healing Oil, Soap, roots and herbs which I took.
JazmineDavis
not rated yet Apr 14, 2018
Am here to testify of the miraculous work of a great traditional doctor called DR.ZUKU ..I have been suffering from Herpes since last 2 years with my Husband but today I am happy that am cure from it with the herbal medicine made by Dr.ZUKU the great healer, I was browsing the internet searching for help when I came across a testimony shared by someone on how Dr.ZUKU cure her from Herpes Disease. I quickly contacted him to get the cure and today i am now free from the Virus, I am so much happy today that we have someone like this great healer out there, so' people out there kindly contact this great doctor on his email address please sir keep your good work cause there are people out there who is in need of your healing medicine .once more contact him now drzukuspelltemple@gmail.com or contact Dr Zuku Blogs . call or text +16177296273 Dr.Zuku can prepare Herbal medicine for all kind of disease. HIV. CANCER. HEPATITIS B.DIABETES.COLD SORES.
Anonym186942
not rated yet Apr 14, 2018
Permanently Eliminate the Herpes Virus from Your Body.
I stand by this herbal cure and remedy to my herpes infection about two month ago,I cant say enough about it .This herbal cure helped me gain the life back that i taught i had lost forever.It completely brought back joy in my life,I have been waiting for this for a long time and am happy and i say a big thank you to kings herbal care solution for completely bring me back and restoring me and i highly recommend this to anyone thats looking for herpes destroying system that actually works.All my friends have used this and says its nothing short of amazingand i also want you tro try this herbal cure and stop contacting fake and hopeless liers some of them lie and rip you off your money and your condition even become worse because when i was looking for cure i met so many fake people that i spent all the money i have laboured for and at the end of the day all was to no avial until i met doctor kings herbal cure through my friend made

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