Altered pain processing after opioid discontinuation

Altered pain processing after opioid discontinuation
The figure depicts BOLD responses to the non-painful (not shown) and painful phase of ascending thermal stimulation during the baseline session across all participants. Credit: Sprenger et al., JNeurosci (2018)

An imaging study of the brain and spinal cord published in JNeurosci reveals pain processing changes in healthy men after receiving a short-term application of a strong opioid. The research provides a plausible mechanism underlying increased pain sensitivity after discontinuation of opioid medication.

Opioids are known to inhibit pain, but it is increasingly recognized that they can also increase sensitivity to pain in certain situations. Dr. Sprenger and colleagues investigated changes in the brain and the spinal cord after application of the potent opioid remifentanil corresponding to increased sensitivity to heat pain stimuli applied to the forearm of healthy male adults.

Functional magnetic resonance imaging found altered signaling in a network that connects frontal brain regions via the brainstem with the that has a crucial role in regulating pain. Since remifentanil has a very short half-life and was mostly cleared from the blood when the changes occurred, these results cannot be attributed to direct effects of the drug. Instead, they indicate altered pain processing in the central nervous system subsequent to opioid application.


Explore further

Understanding pain exacerbation with opioid use

More information: Altered signaling in the descending pain modulatory system after short-term infusion of the μ-opioid agonist remifentanil, JNeurosci (2018). DOI: 10.1523/JNEUROSCI.2496-17.2018
Journal information: Journal of Neuroscience

Citation: Altered pain processing after opioid discontinuation (2018, February 12) retrieved 18 July 2019 from https://medicalxpress.com/news/2018-02-pain-opioid-discontinuation.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
5 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more