Ultrasound for rectal cancer staging tied to more chemoradiation

February 12, 2018

(HealthDay)—Use of endoscopic ultrasound (EUS) for rectal cancer (RC) staging is associated with higher use of neoadjuvant chemoradiation but no significant improvement in overall survival, according to a study published Jan. 26 in the Journal of Gastroenterology and Hepatology.

Philip N. Okafor, M.D., M.P.H., from Stanford University in California, and colleagues used the Surveillance, Epidemiology, and End Results-Medicare database to identify 3,408 patients with nonmetastatic RC between 2005 and 2007. Outcomes were compared between patients who received EUS and computed tomography of the abdomen and pelvis (CTAP) to those staged with CTAP alone.

The researchers found that compared to patients staged with CTAP alone, those who received EUS and CTAP were younger, were more likely male, and had a lower Charlson comorbidity index. Higher socioeconomic status (odds ratio [OR], 1.87), care by a gastroenterologist (OR, 1.713), and care in a teaching hospital (OR, 1.68) predicted EUS. Patients staged with EUS received more neoadjuvant chemoradiation. There was a trend toward longer survival among EUS-staged patients versus those staged with CTAP alone (60 versus 57 months), but this was not statistically significant.

"EUS in RC staging is associated with higher utilization of without a in overall survival," conclude the authors.

Explore further: More than 9-in-10 ED patients who receive CT of the abdomen and pelvis are clinically complex

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

More than 9-in-10 ED patients who receive CT of the abdomen and pelvis are clinically complex

June 1, 2012
The overwhelming majority (93.8 percent) of patients undergoing computed tomography (CT) of the abdomen and pelvis (CTAP) in the emergency department (ED) setting are classified as clinically complex, according to a study ...

Study confirms chemoradiation is best treatment for locally advanced cervical cancer

September 11, 2017
A 14-year randomised trial in more than 600 patients has concluded that chemoradiation should remain the standard treatment for patients with locally advanced cervical cancer. The findings are reported today at the ESMO 2017 ...

Decreased survival when surgery refused for esophageal cancer

January 30, 2018
(HealthDay)—Refusing surgery for esophageal cancer (EC) is associated with worse survival, according to a study presented at the annual meeting of The Society of Thoracic Surgeons, held from Jan. 27 to 31 in Fort Lauderdale, ...

MRI diagnostic for differentiating low-grade bladder cancers

January 29, 2018
(HealthDay)—Magnetic resonance (MR) imaging is accurate in differentiating T1 or lower tumors from T2 or higher tumors among patients with bladder cancer, according to a review published in the February issue of Radiology.

Complications of reconstruction surgery differ for transgender patients

January 31, 2018
The risks of penile reconstruction surgery (phalloplasty) appear higher in female-to-male transgender (transmale) patients undergoing gender confirmation surgery, compared to native male (cismale) patients undergoing phalloplasty ...

Not all 80-, 90-year-olds with rectal cancer are treated

August 4, 2017
(HealthDay)—About 15 percent of octogenarians and nonagenarians with stage II/III rectal adenocarcinoma do not receive treatment, according to a study published online July 31 in Cancer.

Recommended for you

Cancer risk associated with key epigenetic changes occurring through normal aging process

February 22, 2018
Some scientists have hypothesized that tumor-promoting changes in cells during cancer development—particularly an epigenetic change involving DNA methylation—arise from rogue cells escaping a natural cell deterioration ...

NEJM reports positive results for larotrectinib against TRK-fusion cancer

February 22, 2018
In 2013, the labs of University of Colorado Cancer Center investigator Robert C. Doebele, MD, PhD, and Dana-Farber Cancer Institute investigator Pasi A. Jänne, MD, PhD reported in Nature Medicine the presence of TRK gene ...

Putting black skin cancer to sleep—for good

February 22, 2018
An international research team has succeeded in stopping the growth of malignant melanoma by reactivating a protective mechanism that prevents tumor cells from dividing. The team used chemical agents to block the enzymes ...

New therapeutic gel shows promise against cancerous tumors

February 21, 2018
Scientists at the UNC School of Medicine and NC State have created an injectable gel-like scaffold that can hold combination chemo-immunotherapeutic drugs and deliver them locally to tumors in a sequential manner. The results ...

Five novel genetic changes linked to pancreatic cancer risk

February 21, 2018
In what is believed to be the largest pancreatic cancer genome-wide association study to date, researchers at the Johns Hopkins Kimmel Cancer Center and the National Cancer Institute, and collaborators from over 80 other ...

Similarities found in cancer initiation in kidney, liver, stomach, pancreas

February 21, 2018
Recent research at Washington University School of Medicine in St. Louis demonstrated that mature cells in the stomach sometimes revert back to behaving like rapidly dividing stem cells. Now, the researchers have found that ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.