IU-invented microscope could make surgeries more effective, disease diagnoses timelier

March 22, 2018, Indiana University
Microscopic images of normal colon tissue in its native state within the body obtained using a microscope created at the IU School of Medicine. The inset shows microscopic images of normal colon tissue after it has been removed, processed and stained using traditional methods. Credit: Dr. Hany Osman

In the not-so-distant future, surgeons could ensure the complete removal of malignant tumors, and pathologists could analyze tissue more efficiently, by using a device invented at the Indiana University School of Medicine.

Dr. Hany Osman has invented a native-state that is able to scan large areas using . It could allow for immediate, real-time microscopic confirmation of the complete removal of malignant tissues during .

Osman said using conventional microscopes requires a few days of processing to produce an image. It also requires studying tissues that have been removed from the patient, which can make it challenging to pinpoint the exact location where they were removed if surgery is required later.

"For instance, a patient may undergo surgery to remove cancer," Osman said. "After the removed tissues are analyzed, the surgeon may determine that residual cancer still exists. The patient must then go through another procedure to remove it.

"The native-state microscope could be applied directly to the tissues during surgery to confirm that—at a microscopic level—we've removed the malignancy, thus improving the effectiveness of these surgeries," he said. "The microscope incorporates a combination of fiber optics and direct laser treatment. This allows for a two-in-one action of identifying residual malignant within a large area and then eradicating it at a microscopic level."

Microscopic images of normal breast tissue in its native state within the body obtained using a microscope created at the IU School of Medicine. The inset shows microscopic images of normal breast tissue after it has been removed, processed and stained using traditional methods. Credit: Indiana University

Osman said the microscope could also be used by pathologists during medical diagnoses.

"A native-state microscope eliminates the necessity of a physical biopsy by bringing the microscope directly to the diseased tissues," he said. "A pathologist is then able to determine immediately whether the tissues are malignant or benign, allowing us to accurately locate malignant tissues and treat them on-site."

Osman disclosed the invention to the IU Office of Technology Commercialization, which protects, markets and licenses intellectual property developed at Indiana University so it can be commercialized by industry. Osman is currently a fellow at Massachusetts General Hospital, Harvard Medical School in Boston.

Osman said the next step to develop the native-state microscope is performing clinical trials that will optimize the device and harness its capacity.

Explore further: Microscope can scan tumors during surgery and examine cancer biopsies in 3-D

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