IU-invented microscope could make surgeries more effective, disease diagnoses timelier

March 22, 2018, Indiana University
Microscopic images of normal colon tissue in its native state within the body obtained using a microscope created at the IU School of Medicine. The inset shows microscopic images of normal colon tissue after it has been removed, processed and stained using traditional methods. Credit: Dr. Hany Osman

In the not-so-distant future, surgeons could ensure the complete removal of malignant tumors, and pathologists could analyze tissue more efficiently, by using a device invented at the Indiana University School of Medicine.

Dr. Hany Osman has invented a native-state that is able to scan large areas using . It could allow for immediate, real-time microscopic confirmation of the complete removal of malignant tissues during .

Osman said using conventional microscopes requires a few days of processing to produce an image. It also requires studying tissues that have been removed from the patient, which can make it challenging to pinpoint the exact location where they were removed if surgery is required later.

"For instance, a patient may undergo surgery to remove cancer," Osman said. "After the removed tissues are analyzed, the surgeon may determine that residual cancer still exists. The patient must then go through another procedure to remove it.

"The native-state microscope could be applied directly to the tissues during surgery to confirm that—at a microscopic level—we've removed the malignancy, thus improving the effectiveness of these surgeries," he said. "The microscope incorporates a combination of fiber optics and direct laser treatment. This allows for a two-in-one action of identifying residual malignant within a large area and then eradicating it at a microscopic level."

Microscopic images of normal breast tissue in its native state within the body obtained using a microscope created at the IU School of Medicine. The inset shows microscopic images of normal breast tissue after it has been removed, processed and stained using traditional methods. Credit: Indiana University

Osman said the microscope could also be used by pathologists during medical diagnoses.

"A native-state microscope eliminates the necessity of a physical biopsy by bringing the microscope directly to the diseased tissues," he said. "A pathologist is then able to determine immediately whether the tissues are malignant or benign, allowing us to accurately locate malignant tissues and treat them on-site."

Osman disclosed the invention to the IU Office of Technology Commercialization, which protects, markets and licenses intellectual property developed at Indiana University so it can be commercialized by industry. Osman is currently a fellow at Massachusetts General Hospital, Harvard Medical School in Boston.

Osman said the next step to develop the native-state microscope is performing clinical trials that will optimize the device and harness its capacity.

Explore further: Microscope can scan tumors during surgery and examine cancer biopsies in 3-D

Related Stories

Microscope can scan tumors during surgery and examine cancer biopsies in 3-D

June 26, 2017
When women undergo lumpectomies to remove breast cancer, doctors try to remove all the cancerous tissue while conserving as much of the healthy breast tissue as possible.

Multimodal biomicroscopic system enhances the accuracy of cancer treatment

January 9, 2018
A research team of Information and Communication Engineering at DGIST has developed the world's first multimodal biomicroscopic system to analyze the characteristics of tumors and to utilize them in tumor treatment technology ...

Ultrasound microscopy: An aid for surgeons to make the invisible, visible

December 10, 2013
Professor Naohiro Hozumi of Toyohashi Tech is developing the technology to monitor living tissue and cell specimens for medical purposes.

Machines see the future for patients diagnosed with brain tumors

March 13, 2018
For patients diagnosed with glioma, a deadly form of brain tumor, the future can be very uncertain. While gliomas are often fatal within two years of diagnosis, some patients can survive for 10 years or more. Predicting the ...

Laser-based imaging tool could increase accuracy, safety of brain tumor surgery

October 15, 2015
Brain tumor tissue can be hard to distinguish from normal brain during surgery. Neurosurgeons use their best judgment in the operating room but often must guess exactly where the edges of the tumor are while removing it.

Recommended for you

First immunotherapy success for triple-negative breast cancer

October 21, 2018
There is new hope for people with an aggressive type of breast cancer, as an immunotherapy trial shows for the first time that lives can be extended in people with triple-negative breast cancer.

Healthy diets linked to better outcomes in colorectal cancer

October 20, 2018
Colorectal cancer patients who followed healthy diets had a lower risk of death from colorectal cancer and all causes, even those who improved their diets after being diagnosed, according to a new American Cancer Society ...

Why some cancers affect only young women

October 19, 2018
Among several forms of pancreatic cancer, one of them specifically affects women, often young. How is this possible, even though the pancreas is an organ with little exposure to sex hormones? This pancreatic cancer, known ...

Scientists to improve cancer treatment effectiveness

October 19, 2018
Together with researchers from the University of Nantes and the University of Reims Champagne-Ardenne in France, experts from the National Research Nuclear University MEPhI have recently developed a quantum dot-based microarray ...

Mutant cells colonize our tissues over our lifetime

October 18, 2018
By the time we reach middle age, more than half of the oesophagus in healthy people has been taken over by cells carrying mutations in cancer genes, scientists have uncovered. By studying normal oesophagus tissue, scientists ...

Study involving hundreds of patient samples may reveal new treatment options of leukemia

October 17, 2018
After more than five years and 672 patient samples, an OHSU research team has published the largest cancer dataset of its kind for a form of leukemia. The study, "Functional Genomic Landscape of Acute Myeloid Leukemia", published ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.