Mesenchymal stem cell therapy: Holding promise for feline inflammatory diseases

March 13, 2018, SAGE Publications
Feline patient receiving adipose-derived stem cells intravenously as part of a study to assess the safety and efficacy of this innovative treatment for chronic kidney disease. Credit: Jessica Quimby

Stem cell therapy is acknowledged as having great potential for the treatment of a variety of diseases in both people and animals. The use of bone marrow-derived stem cells is well established in the treatment of human cancer patients, and veterinary applications for bone marrow- and adipose-derived stem cells are being evaluated.

The present and potential clinical applications of therapy in cats are explored in a state-of-the-art review article published this month in the Journal of Feline Medicine and Surgery.

The review's authors, Dr Jessica Quimby, of the Department of Veterinary Clinical Sciences at Ohio State University, and Dr Dori Borjesson, of the Veterinary Institute for Regenerative Cures at the University of California-Davis, consider the emergence of this new therapeutic strategy and the current understanding of the biology and immunology of mesenchymal .

They also summarise the outcome of clinical trials that have investigated the use of mesenchymal stem in the of a number of inflammatory, degenerative and immune-mediated diseases of cats. Management of these conditions conventionally requires lifelong use of medication, with the potential for associated side effects. Some cats may not respond to standard treatment regimens, and the medication may not prevent progression of the underlying disease.

Trials of stem cell therapy for conditions such as feline chronic gingivostomatitis, a severe, painful oral disease estimated to affect up to 12% of cats presenting to veterinary practices, have produced encouraging results. So, too, have trials for enteropathies, such as inflammatory bowel disease, and for asthma. The treatment has been generally well tolerated, with few side effects and, in some cases, has proved curative. The use of stem cells in the treatment of feline chronic kidney disease, however, has been the exception. None of the studies conducted so far in cats have been able to replicate results seen in experimental models in rodents, where definitive decreases in kidney values were seen.

The authors conclude that mesenchymal has great potential as a therapeutic option in feline , but that many questions about the logistics of its use remain to be answered. What is the ideal source of stem cells? What is the optimal route of administration? And what impact does tissue donor status have on stem cell function? Further research is already underway to investigate these aspects of this promising .

Explore further: Researchers study stem-cell therapy for feline kidney disease

Related Stories

Researchers study stem-cell therapy for feline kidney disease

January 9, 2014
Chronic kidney disease in older cats is the focus of a fifth clinical trial under way at Colorado State University's James L. Voss Veterinary Teaching Hospital, where veterinarians are exploring novel stem-cell therapy that ...

Study shows adipose stem cells may be the cell of choice for therapeutic applications

February 24, 2017
An international team of researchers, funded by Morris Animal Foundation, has shown that adipose (fat) stem cells might be the preferred stem cell type for use in canine therapeutic applications, including orthopedic diseases ...

Cat stem cell therapy gives humans hope

February 2, 2016
By the time Bob the cat came to the UC Davis veterinary hospital, he had used up most of his nine lives. Afflicted with a painful oral inflammatory disorder, Bob had already lost all of his teeth in an effort to treat the ...

Sub-set of stem cells found to minimize risks when used to treat damaged hearts

July 25, 2016
Scientists use mathematical modeling to simulate human mesenchymal stem cell delivery to a damaged heart and found that using one sub-set of these stem cells minimises the risks associated with this therapy. The study, published ...

Veterinary surgeons use feline adult stem cells in kidney transplant

June 18, 2014
Veterinary surgeons in the University of Georgia Veterinary Teaching Hospital successfully performed a kidney transplant in a domestic cat and used stem cells harvested from the patient to optimize the cat's acceptance of ...

Scientists find way to predict activity of stem cells

February 29, 2016
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have for the first time developed a way to predict how a specific type of stem cell will act against different diseases. With more than 500 stem ...

Recommended for you

Patchy distribution of joint inflammation resolved

November 16, 2018
Chronic inflammatory rheumatic diseases such as rheumatoid arthritis (RA) and spondylo-arthritis (SpA) are chronic, disabling diseases with a poor outcome for loco-motoric function if left untreated. RA and SpA each affect ...

Can't exercise? A hot bath may help improve inflammation, metabolism, study suggests

November 14, 2018
Hot water treatment may help improve inflammation and blood sugar (glucose) levels in people who are unable to exercise, according to a new study. The findings are published ahead of print in the Journal of Applied Physiology.

Inflammation can lead to circadian sleep disorders

October 31, 2018
Inflammation, which is the root cause of autoimmune disorders including arthritis, Type 1 diabetes, irritable bowel syndrome and Crohn's disease, has unexpected effects on body clock function and can lead to sleep and shiftwork-type ...

Machine learning tool predicts the potential of peptides as immune activators

October 23, 2018
The immune system keeps T cells under control by regulating precisely when they can respond to a pathogen. For instance, helper T cells only turn "on" if other immune cells, such as antigen-presenting cells (APCs) present ...

A new mechanism in the control of inflammation

October 18, 2018
After infection or tissue injury, the inflammatory immune response attacks the infection and repairs the damaged tissue. However, sometimes excess inflammation can have the opposite effect, increasing injury in a process ...

Sugar, a 'sweet' tool to understand brain injuries

October 15, 2018
Australian researchers have developed ground-breaking new technology which could prove crucial in treating brain injuries and have multiple other applications, including testing the success of cancer therapies.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.