Crosstalk between cells plays role in pulmonary hypertension

April 25, 2018 by Ziba Kashef, Yale University
Crosstalk between cells plays role in pulmonary hypertension
Image shows accumulation of specialized immune system cells around tiny arteries in lungs of mice with pulmonary hypertension. Staining shows different cell types: macrophage (green), smooth muscle (red), and endothelial cell (white). Credit: Yale University

Pulmonary hypertension is a type of high blood pressure that affects blood vessels in the lungs. Once diagnosed, patients have limited treatment options, and many do not live beyond seven years. In a new study, scientists in the Yale Cardiovascular Research Center have gained new insight into the development of the disease that could lead to new therapies.

First author Abdul Sheikh and senior author Daniel Greif had previously identified specialized cells in the smooth muscle of in the lungs of mice with pulmonary hypertension (PH), as well as in human cells. In this latest study, Shiekh, Greif, and colleagues focused on molecular signals between the specialized cells and other cells in the arteries of mice models of PH. They found there were signals, or crosstalk, between the different cell types that caused the specialized cells to multiply and migrate. This cell proliferation and migration leads to the narrowing and blockage of arteries in the lung that characterizes the disease.

These findings deepen understanding of mechanisms underlying this chronic, often lethal disease. With further study, the researchers aim to pinpoint a specific target for therapies to treat earlier and more effectively.

The study was published in Cell Reports

Explore further: Scientists identify potential therapeutic target for pulmonary hypertension

More information: Abdul Q. Sheikh et al. Cell Autonomous and Non-cell Autonomous Regulation of SMC Progenitors in Pulmonary Hypertension, Cell Reports (2018). DOI: 10.1016/j.celrep.2018.03.043

Related Stories

Scientists identify potential therapeutic target for pulmonary hypertension

October 8, 2015
Cardiovascular diseases are the leading cause of death worldwide. As a prime example, pulmonary hypertension is especially lethal, with one-half of patients dying within three years of being diagnosed. Yale researchers have ...

By zooming in on arteries, researcher gets to the root of pulmonary hypertension

February 27, 2014
You might think building muscle is a good thing, but that's often not so in the case of blood vessels in adults. In fact, excess smooth muscle is a root problem in many vascular diseases, as it causes arteries to constrict ...

Genetic study could lead to new treatments for sufferers of pulmonary arterial hypertension

April 13, 2018
Research carried out by a consortium including St George's, University of London has identified new genes for pulmonary arterial hypertension, which provides renewed hope for people affected with this incurable condition.

New targets for treating pulmonary hypertension found

September 8, 2014
Two new potential therapeutic targets for the treatment of pulmonary arterial hypertension, a deadly disease marked by high blood pressure in the lungs, have been identified by researchers at the University of Illinois at ...

Pulmonary artery stiffening is an early driver of pulmonary hypertension

June 2, 2016
Pulmonary hypertension is an abnormal elevation of pressure in the pulmonary circulation that results in stress on the heart and remodeling of blood vessels in the lung. Pulmonary hypertension is caused by a variety of factors, ...

Genes on Y chromosome protect against pulmonary hypertension, study suggests

December 5, 2017
A new UCLA study suggests that the Y chromosome provides protection against the development of pulmonary hypertension and may be the reason the disease is less prevalent among men than women. The researcher found that mice ...

Recommended for you

Gene plays critical role in noise-induced deafness

October 19, 2018
In experiments using mice, a team of UC San Francisco researchers has discovered a gene that plays an essential role in noise-induced deafness. Remarkably, by administering an experimental chemical—identified in a separate ...

Functional engineered oesophagus could pave way for clinical trials 

October 18, 2018
The world's first functional oesophagus engineered from stem cells has been grown and successfully transplanted into mice, as part of a pioneering new study led by UCL.

New findings cast light on lymphatic system, key player in human health

October 16, 2018
Scientists at the Oklahoma Medical Research Foundation have broken new ground in understanding how the lymphatic system works, potentially opening the door for future therapies.

New model suggests cuffless, non-invasive blood pressure monitoring possible using pulse waves

October 16, 2018
A large team of researchers from several institutions in China and the U.S. has developed a model that suggests it should be possible to create a cuffless, non-invasive blood pressure monitor based on measuring pulse waves. ...

Age-related increase in estrogen may cause common men's hernia

October 16, 2018
An age-related increase in estrogen may be the culprit behind inguinal hernias, a condition common among elderly men that often requires corrective surgery, according to a Northwestern Medicine study was published Oct. 15 ...

Income and wealth affect the mental health of Australians, study shows

October 16, 2018
Australians who have higher incomes and greater wealth are more likely to experience better mental health throughout their lives, new research led by the Bankwest Curtin Economics Centre has found.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.