What if you could know that your mild cognitive impairment wouldn't progress

April 24, 2018, IOS Press

Researchers from the Lisbon School of Medicine, University of Lisbon found that, in some mild cognitive impairment patients, real neuropsychological stability over a decade is possible and that long-term stability could be predicted based on neuropsychological tests measuring memory and non-verbal abstract reasoning.

In their work, with 10 years of follow-up, independently of the association of one verbal memory delayed measure at baseline with long-term , the performance on the Raven's Progressive Matrices at the baseline was the stronger neuropsychological predictor of long-term clinical stability. Each additional point in the total score of the Raven's Progressive Matrices at baseline increased the probability of long-term stability about 2 fold.

Raven's Progressive Matrices constitute a non-verbal reasoning measure of ?uid-type intelligence, which is predictive of a general ability to do well, calling for novel problem solving and re?ecting current ability for abstract thought and reasoning. Although the diagnosis of (MCI) corresponds to a condition likely to progress to dementia, it is known that some may maintain the diagnosis of MCI even after many years.

The team at the Faculty of Medicine of Lisbon sought to determine whether patients that maintain the diagnosis of MCI in the long term were really stable or just declining slowly, and to identify baseline neuropsychological characteristics associated with long-term stability.

Participants were selected from the Cognitive Complaints Cohort (CCC), established in a prospective study conducted at the Faculty of Medicine, University of Lisbon, to investigate the cognitive stability or evolution to dementia of patients with cognitive complaints, based on a comprehensive neuropsychological evaluation and other biomarkers.

The Cognitive Complaints Cohort (CCC) was searched for MCI cases who maintained that diagnosis for at least 10 years. For each long-term-stable MCI patient, two MCI patients that converted to dementia during follow-up, matched for age and education, were selected from the same database.

Twenty-two patients in the CCC met criteria for long-term-stable MCI, representing 3.4% of the 655 MCI patients having follow-up in the CCC.Time of follow-up was on average 11 years for long-term-stable MCI and 3 years for converter MCI.

The baseline and follow-up were not significantly different in long-term-stable MCI patients, whereas a general decline was observed in converter MCI patients.

Higher scores on one memory test, the Word Delayed Total Recall, and on the non-verbal abstraction test, Raven's Progressive Matrices, at the baseline predicted long-term (10 years) clinical stability.

"It was striking to find that some patients with MCI do remain clinically and neuropsychologically stable for a decade" said Luísa Alves, first author of the study.

"The proportion of long term stable MCI was higher than we anticipated" commented Manuela Guerreiro, the neuropsychologist who evaluated the participants. "We were surprised to find that the long term clinical stability of MCI patients corresponded to real neuropsychological stability in all the studied cognitive domains" said Alexandre de Mendonça, chief Investigator at the Faculty of Medicine.

"It was puzzling to be able to predict long term stability based on simple neuropsychological tests" referred Dina Silva, co-funder of the CCC.

Explore further: The role of verb fluency in the detection of early cognitive impairment in Alzheimer's disease

More information: Luísa Alves et al, Neuropsychological Predictors of Long-Term (10 Years) Mild Cognitive Impairment Stability, Journal of Alzheimer's Disease (2018). DOI: 10.3233/JAD-171034

Related Stories

The role of verb fluency in the detection of early cognitive impairment in Alzheimer's disease

March 16, 2018
The ability to generate spoken verbs in infinitive in a given time begins to worsen in the early stages of Alzheimer's disease (AD). Thus, the verb fluency test has been found to be a suitable neuropsychological tool for ...

Multiple sclerosis researchers find role for working memory in cognitive reserve

September 9, 2014
Kessler Foundation scientists have shown that working memory may be an underlying mechanism of cognitive reserve in multiple sclerosis (MS). This finding informs the relationships between working memory, intellectual enrichment ...

Delirium in older patients after surgery may lead to long-term cognitive decline

July 14, 2016
Researchers from the Harvard Medical School - affiliated Hebrew SeniorLife Institute for Aging Research (IFAR) have found increasing evidence that delirium in older surgical patients may be associated with long-term cognitive ...

Mild cognitive decline in nearly half lacunar stroke patients

August 27, 2012
(HealthDay)—Mild cognitive impairment (MCI) is present in nearly half of patients with lacunar stroke, according to a study published online Aug. 18 in the Annals of Neurology.

Most patients taking warfarin long-term do not maintain stable INR values

August 9, 2016
In a study appearing in the August 9 issue of JAMA, Sean D. Pokorney, M.D., M.B.A., Eric D. Peterson, M.D., M.P.H., of Duke University Medical Center, Durham, N.C., and colleagues examined whether patients receiving warfarin ...

Long-term neuropsychological impairment is common in acute lung injury survivors

April 6, 2012
Cognitive and psychiatric impairments are common among long-term survivors of acute lung injury (ALI), and these impairments can be assessed using a telephone-based test battery, according to a new study.

Recommended for you

Scientists discover why some people with brain markers of Alzheimer's have no dementia

August 16, 2018
A new study from The University of Texas Medical Branch at Galveston has uncovered why some people that have brain markers of Alzheimer's never develop the classic dementia that others do. The study is now available in the ...

Researchers identify new genes that may contribute to Alzheimer's disease

August 14, 2018
Researchers from Boston University School of Medicine, working with scientists across the nation on the Alzheimer's Disease Sequencing Project (ADSP), have discovered new genes that will further current understanding of the ...

Deaths from resident-to-resident incidents in dementia offers insights to inform policy

August 14, 2018
Analyzing the incidents between residents in dementia in long-term care homes may hold the key to reducing future fatalities among this vulnerable population, according to new research from the University of Minnesota School ...

Scientists propose a new lead for Alzheimer's research

August 14, 2018
A University of Adelaide-led team of scientists has suggested a potential link between iron in our cells and the rare gene mutations that cause Alzheimer's disease, which could provide new avenues for future research.

Eye conditions provide new lens screening for Alzheimer's disease

August 8, 2018
Alzheimer's disease is difficult to diagnose as well as treat, but researchers now have a promising new screening tool using the window to the brain: the eye.

Potential indicator for the early detection of dementias

August 7, 2018
Researchers at the University of Basel have discovered a factor that could support the early detection of neurodegenerative diseases such as Alzheimer's or Parkinson's. This cytokine is induced by cellular stress reactions ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.