Dual-hormone system may lower time in hypoglycemia in T1DM

Dual-hormone system may lower time in hypoglycemia in T1DM

(HealthDay)—For physically active adults with type 1 diabetes, the addition of glucagon delivery to a closed-loop system using wearable sensors with automated exercise detection is associated with reduced hypoglycemia, according to a study published online May 11 in Diabetes Care.

Jessica R. Castle, M.D., from the Oregon Health & Science University in Portland, and colleagues enrolled 20 participants with type 1 . Participants underwent dual-hormone, single-hormone, predictive low glucose suspend, and continuation of current care over four days in a randomized order. Three moderate-intensity aerobic exercise sessions were included in each arm.

The researchers found that the lowest mean time in hypoglycemia was seen with dual-hormone during the exercise period (3.4 percent versus 8.3 [P = 0.009], 7.6 [P < 0.001], and 4.3 percent [P = 0.49] for single-hormone, predictive low glucose suspend, and current care, respectively). During the entire four-day study, time in hypoglycemia was also lowest with dual-hormone (1.3 percent versus 2.8 [P < 0.001), 2.0 [P = 0.04], and 3.1 percent [P = 0.007] for single-hormone, predictive low glucose suspend, and current care, respectively). During the entire study, time in range was the highest with single-hormone (74.3 percent, versus 72.0 percent with dual-hormone; P = 0.44).

"The addition of glucagon delivery to a closed-loop system with automated detection reduces in physically active adults with type 1 diabetes," the authors write.

Two authors disclosed financial ties to Pacific Diabetes Technologies.

More information: Abstract/Full Text (subscription or payment may be required)

Journal information: Diabetes Care

Copyright © 2018 HealthDay. All rights reserved.

Citation: Dual-hormone system may lower time in hypoglycemia in T1DM (2018, May 16) retrieved 28 March 2024 from https://medicalxpress.com/news/2018-05-dual-hormone-hypoglycemia-t1dm.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Closed-loop insulin delivery promising in T1DM pregnancy

2 shares

Feedback to editors