Study compares neuropsychological tests for assessing deficits in MS

May 24, 2018, Kessler Foundation

A recent article by Kessler Foundation researchers compared two neuropsychological tests for assessing learning in individuals with multiple sclerosis (MS). The article, "Comparing the Open Trial—Selective Reminding Test results with the California Learning Verbal Test II in Multiple Sclerosis" was published online on April 4, 2018, in Applied Neuropsychology: Adult.

This is the first study to compare the two tests in the same individuals with MS. The authors are Silvana L. Costa, Ph.D., John DeLuca, Ph.D., Kristen Costanza and Nancy Chiaravalloti, Ph.D. of Kessler Foundation.

Researchers administered the tests to 112 individuals with MS, 79 women and 33 men. Results showed clear differences in performance on the California Verbal Learning Test (CVLT-II) and the Open Trial Selective Reminding Test (OT-SRT). On the OT-SRT, all participants were identified as impaired, while only 34 percent were similarly identified on the CLV-TII. Differences in administration of the tests may explain this disparity. With the OT-SRT learning and memory are tested with minimal reliance on other . With the CVLTII, reliance on other cognitive abilities is more prominent, likely affecting the testing results.

"It is essential that the accurately pinpoint the deficits in MS," said Dr. Costa, the lead author. "This is fundamental to developing interventions to address these deficits, and tailoring cognitive rehabilitation programs for maximal outcomes in this population."

Explore further: MS researchers correlate BICAMS and performance of everyday life activities

More information: Silvana L. Costa et al, Comparing the Open Trial – Selective Reminding Test results with the California Learning Verbal Test II in multiple sclerosis, Applied Neuropsychology: Adult (2018). DOI: 10.1080/23279095.2018.1448818

Related Stories

MS researchers correlate BICAMS and performance of everyday life activities

September 24, 2015
Kessler Foundation scientists found that the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) predicted performance of activities of daily living using Actual Reality (AR). The article, "Brief International ...

Benefits of modified Story Memory Technique may be adversely affected by deficit in processing speed

April 10, 2015
Kessler Foundation researchers published a subanalysis of their MEMREHAB trial, which shows that treatment with the modified Story Memory Technique (mSMT) may be affected by cognitive dysfunction. Investigators looked at ...

Study provides Class 1 evidence for cognitive training efficacy in TBI

September 10, 2015
Kessler Foundation researchers published results of a randomized clinical trial (RCT) of a cognitive intervention to improve learning and memory in individuals with traumatic brain injury (TBI) - the TBI-MEM trial. The treatment ...

Scientists confirm effectiveness of cognitive rehabilitation in multiple sclerosis

August 8, 2014
Kessler Foundation researchers published long-term followup results of their MEMREHAB trial, which show that in individuals with MS, patterns of brain activity associated with learning were maintained at 6 months post training. ...

Scientists link slowed processing speed with executive deficits in MS

September 16, 2014
Kessler Foundation researchers have published a study supporting the role of slowed processing speed in the executive deficits found in individuals with multiple sclerosis (MS). "Does slowed processing speed account for executive ...

Researchers correlate cognitive fatigue after TBI with activation of the caudate

September 1, 2017
Kessler Foundation researchers have authored a new article that further elucidates the mechanisms for cognitive fatigue, a disabling symptom that affects many individuals after traumatic brain injury (TBI). The article, "Cognitive ...

Recommended for you

Study of protein 'trafficker' provides insight into autism and other brain disorders

September 22, 2018
In the brain, as in business, connections are everything. To maintain cellular associates, the outer surface of a neuron, its membrane, must express particular proteins—proverbial hands that reach out and greet nearby cells. ...

Breast milk may be best for premature babies' brain development

September 21, 2018
Babies born before their due date show better brain development when fed breast milk rather than formula, a study has found.

White matter repair and traumatic brain injury

September 20, 2018
Traumatic brain injury (TBI) is a leading cause of death and disability in the U.S., contributing to about 30 percent of all injury deaths, according to the CDC. TBI causes damage to both white and gray matter in the brain, ...

'Gut sense' is hardwired, not hormonal

September 20, 2018
If you've ever felt nauseous before an important presentation, or foggy after a big meal, then you know the power of the gut-brain connection.

Gut branches of vagus nerve essential components of brain's reward and motivation system

September 20, 2018
A novel gut-to-brain neural circuit establishes the vagus nerve as an essential component of the brain system that regulates reward and motivation, according to research conducted at the Icahn School of Medicine at Mount ...

Genomic dark matter activity connects Parkinson's and psychiatric diseases

September 20, 2018
Dopamine neurons are located in the midbrain, but their tendril-like axons can branch far into the higher cortical areas, influencing how we move and how we feel. New genetic evidence has revealed that these specialized cells ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.