Strong link between depression and anxiety disorders with chronic thyroid disease

May 15, 2018, University of Erlangen-Nuremberg

There is a strong link between depression and anxiety disorders and autoimmune thyroiditis (AIT), a chronic thyroid condition affecting approximately 10 percent of the population. Scientists at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) have now proven that special treatment could help many sufferers, especially women.

Depression and are among the most common psychiatric disorders across the globe. In 2016 more than 260,000 patients were admitted to hospital for treatment in Germany alone, according to statistics from the Federal Statistics Office.

Along with collaborators, Dr. Teja Wolfgang Grömer, medical practitioner in Bamberg and lecturer at the Chair of Psychiatry and Psychotherapy, has now proven a strong link between depression and and autoimmune thyroiditis. "Over the years, I must have been consulted by several hundred people suffering from depression and anxiety," reports the psychiatrist and former Max-Planck researcher. "At the end of 2015, I noticed a marked connection between AIT and the other two conditions, especially in patients suffering from both. After realising that more than one in two people diagnosed with anxiety and depression—and only in these cases, not other conditions—also tested positive for antibodies, I decided to investigate the issue in more detail." With the help of the co-authors and a student of psychology at the University of Bamberg, Eva-Maria Siegmann, Dr. Grömer drew up a systematic overview of the current state of research and calculated the strength of the connection on the basis of statistics. For his metastudy, Dr. Grömer combined 21 independent studies based on a total of 36,174 participants. 35,168 of the participants suffered from depression and 34,094 from anxiety.

Dr. Grömer says, "Most patients felt a sense of relief after receiving the diagnosis, as very often, they had been left with no explanation for their symptoms." Autoimmune thyroiditis leads to a lasting inflammation of the thyroid gland. Hormones from the thyroid influence the metabolism and cellular energy balance as well as perceived energy levels and the psyche. AIT leads to specific mental symptoms, including inner unrest, tension and exhaustion. People tend to fall ill between the ages of 30 and 50, with women being affected considerably more often than men. As the disease often first becomes apparent around the same time as the menopause and tends not to cause any pain, it is easy to miss the inflammation of the , or misdiagnose it as 'menopausal symptoms' or depression or anxiety alone.

The fact is that calculations have shown that patients with AIT are 3.5 times more likely to suffer from depression, or 2.3 times more likely to suffer from anxiety. This doesn't sound like much at first, but as all three disorders are very common, it means that patients with AIT account for more than 40 percent of all cases of depression and 30 percent of all cases of anxiety. Dr. Grömer gives a detailed description of the disease in his article.

The article reports thorough research of relevant literature showing that if doctors recognise the links between the disorders, they can prescribe a special treatment and use antidepressants that do not affect patients' weight and the trace element selenium from an early stage. Ensuring that patients are well informed is crucial. Dr. Grömer therefore recommends screening all diagnosed with depression and anxiety for AIT, determining which antibodies they have. In addition, in future psychiatric research on or anxiety, AIT sufferers should be recognised as a separate group in order to cast more light on the connections.

Explore further: Increased prevalence of depression, anxiety after colorectal cancer

More information: Eva-Maria Siegmann et al, Association of Depression and Anxiety Disorders With Autoimmune Thyroiditis, JAMA Psychiatry (2018). DOI: 10.1001/jamapsychiatry.2018.0190

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