Discovery of kidney structure challenges current understanding of renal physiology

Discovery of kidney structure challenges current understanding of renal physiology
Multiphoton imaging of glomeruli. Images were obtained by combining two photon fluorescence (TPF) signal images with second harmonic generation (SHG) images of an unfixed human glomerulus. Credit: University of Bristol

New research by the University of Bristol has found that the microscopic structure of human kidney is different to what was previously known.

The kidney is a key organ balancing blood and body chemistry through filtration and reabsorption. The control of blood flow and pressure through the kidney is crucial for maintaining this process.

Researchers at the Universities of Bristol, Exeter and Nottingham have been investigating the of the human glomerulus, tiny 0.2mm tight knots of thin walled blood vessels which allow the filtration of blood into attached tubules within the kidney. Previous studies into this have avoided using the physiological pressures of blood in preparing the kidney. Much like pumping up a tyre, without the correct pressure, the tiny blood vessels and tubules within the kidney structure collapse when removed from the body, which leads to misinterpretation when studied under the microscope.

The paper 'Novel Haemodynamic structures in the human glomerulus', published in American Journal of Physiology, has shown that human glomerular blood architecture is not as depicted in current texts. Accurate 3-D reconstruction of the glomeruli has defined new blood vessel regions, called vascular chambers (VC) which challenge current narratives of the human glomerulus developed over the last 170 years.

The work involved microscopic accuracy as the glomerular blood vessel structures are minute. A filtering human glomerulus is 0.2mm in diameter and the attached reabsorbing tubule is a 5cm long but only 0.06mm diameter—over a million of these fit into two fist sized kidneys. 3-D reconstructions were made from fresh or fixed human kidney cortex using conventional light microscopy, confocal microscopy, multiphoton microscopy and transmission electron microscopy.

These newly discovered structures may play a role controlling the flow of and filtrate and pressure balance in the human glomerulus. The unusual finding is that smaller species appear to lack VC and smaller glomeruli (such as those found in children) may not contain VC as they scale with the glomerular size and are just too small to have VC, but this remains to be confirmed.

By understanding the in-depth structure and physiology of the kidney, researchers will better understand kidney diseases. Lead author of the study Chris Neal from the University of Bristol, believes this finding may have a huge impact on understanding a wide variety of diseases.


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More information: Christopher R. Neal et al. NOVEL HAEMODYNAMIC STRUCTURES IN THE HUMAN GLOMERULUS, American Journal of Physiology-Renal Physiology (2018). DOI: 10.1152/ajprenal.00566.2017
Journal information: American Journal of Physiology

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