Older age tied to poorer course of major depressive disorder

June 8, 2018

(HealthDay)—Older age is associated with poorer course of major depressive disorder (MDD), according to a study published online June 7 in The Lancet Psychiatry.

Roxanne Schaakxs, Ph.D., from VU University Medical Center in Amsterdam, and colleagues obtained data for 1,042 participants with MDD at baseline, who had data available at baseline and two-year follow-up. The primary outcome was the two-year course of MDD, assessed with four indicators.

The researchers observed a significant correlation for with a worse two-year MDD course for all four indicators (MDD diagnosis: odds ratio, 1.08; chronic symptom course: odds ratio, 1.24; time to remission: hazard ratio, 0.91; and depression severity change: regression coefficient, 1.06). The MDD course worsened linearly with age; the worst outcomes were seen for people aged 70 years and older compared with those of the reference group aged 18 to 29 years (MDD diagnosis: odds ratio, 2.02; chronic symptom course, odds ratio, 3.19; time to remission: hazard ratio, 0.60; and depression severity change: −12.64 and −5.57 in those aged 18 to 29 and 70 years or older, respectively). After adjustment for prognostic clinical, social, and health factors, the results were slightly attenuated, but remained mostly significant.

"Further investigation of potential underlying mechanisms—including the effect of cognitive impairment, for example—is needed to prevent the negative consequences of a long-term MDD burden in older people," the authors write.

One author disclosed financial ties to the pharmaceutical industry.

Explore further: Intellectual activities in later life may cut dementia risk

More information: Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Related Stories

Intellectual activities in later life may cut dementia risk

June 7, 2018
(HealthDay)—Active participation in intellectual activities among adults aged 65 years or older is associated with reduced risk of dementia, according to a study published online May 30 in JAMA Psychiatry.

Depression ups mortality risk post aortic valve replacement

February 4, 2018
(HealthDay)—The presence of depressive symptoms among older adults undergoing transcatheter (TAVR) or surgical (SAVR) aortic valve replacement increases the risk of mortality, according to research published online Jan. ...

Insomnia found to be common but mild in older adults

May 30, 2018
(HealthDay)—Insomnia is common in older community-dwelling adults, but usually mild, according to a study published online May 21 in the Journal of the American Geriatrics Society.

Senior CA patients also benefit from palliative radiotherapy

May 30, 2018
(HealthDay)—All patients with painful bone metastasis should be referred for palliative radiotherapy to relieve the pain, regardless of age, according to a study published online May 23 in the Journal of Medical Imaging ...

Various clinical disturbances precede MS diagnosis

May 21, 2018
(HealthDay)—Various clinical symptoms precede the diagnosis of multiple sclerosis (MS) by several years, according to a study published online May 8 in the Annals of Neurology.

Early intervention services best for early-phase psychosis

May 7, 2018
(HealthDay)—Early intervention services (EIS) are better than treatment as usual (TAU) for early-phase psychosis across meta-analyzable outcomes, according to a review published online May 2 in JAMA Psychiatry.

Recommended for you

People are more honest when using a foreign tongue, research finds

August 17, 2018
New UChicago-led research suggests that someone who speaks in a foreign language is probably more credible than the average native speaker.

FDA approves brain stimulation device for OCD

August 17, 2018
(HealthDay)—A brain stimulation device to treat obsessive-compulsive disorder (OCD) has received approval for marketing Friday by the U.S. Food and Drug Administration.

Research eyes role of stress in mental illnesses

August 17, 2018
We all face stress in our lives. Even researchers seeking to understand why some people shrug it off while others face battles against disorders like depression or PTSD.

16 going on 66: Will you be the same person 50 years from now?

August 17, 2018
How much do you change between high school and retirement? The answer depends on whether you're comparing yourself to others or to your younger self.

Expecting to learn: Language acquisition in toddlers improved by predictable situations

August 16, 2018
The first few years of a child's life are crucial for learning language, and though scientists know the "when," the "how" is still up for debate. The sheer number of words a child hears is important; that number predicts ...

Letting PTSD patients choose method of treatment improves their health, quality of life: new research

August 16, 2018
Letting people with post-traumatic stress disorder (PTSD) choose between treatment methods improves their quality of life and reduces the disorder's symptoms, according to new research from Case Western Reserve University.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.