Sex, drugs, and heart failure

Human heart. Credit: copyright American Heart Association

Heart failure is almost as common in women as men, but its characteristics vary by sex. A new review summarizes the current state of sex-sensitive issues related to heart failure drugs included in treatment guidelines, and suggests future directions for improved care.

The authors of the ESC Heart Failure review note that women are largely underrepresented in clinical trials of medications, and that evidence of medications' efficacy in women is limited.

"We have much hope that precision medicine will lead to more efficacious medications. I believe that this will in part be enabled by the conduct of that are more sex-aware," said co-author Dr. Marie-Pierre Dubé, of the Montreal Heart Institute Research Centre.

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Clinical trial enrollment favors men

More information: Anna Levinsson et al, Sex, drugs, and heart failure: a sex-sensitive review of the evidence base behind current heart failure clinical guidelines, ESC Heart Failure (2018). DOI: 10.1002/ehf2.12307
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Citation: Sex, drugs, and heart failure (2018, June 22) retrieved 27 February 2021 from
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