Higher vitamin D levels may lower breast cancer risk

July 13, 2018

(HealthDay)—Higher levels of vitamin D may be protective against breast cancer, according to a study published online June 15 in PLOS ONE.

Sharon L. McDonnell, M.P.H., from GrassrootsHealth in Encinitas, Calif., and colleagues examined the relationship between 25-hydroxyvitamin D (25[OH]D concentration and across a broad range of 25(OH)D concentrations (<20 to ≥60 ng/mL) among women aged 55 years and older participating in three previous studies (pooled cohort, 5,038 participants).

The researchers found that 77 women were diagnosed with breast cancer (age-adjusted incidence: 512 cases per 100,000 person-years). There was an 82 percent lower incidence rate of breast cancer for women with 25(OH)D concentrations ≥60 versus <20 ng/mL (rate ratio [RR], 0.18; P = 0.006). Kaplan-Meier curves for concentrations of <20, 20 to 39, 40 to 59, and ≥60 ng/mL were significantly different, with the highest proportion of breast cancer-free participants in the ≥60 ng/mL group (99.3 percent) and the lowest proportion of breast cancer-free participants in the <20 ng/mL group (96.8 percent) (P = 0.02). When adjusting for age, body mass index, smoking status, calcium supplement intake, and study of origin, women with 25(OH)D concentrations ≥60 ng/mL had an 80 percent lower risk of breast cancer than women with concentrations <20 ng/mL (hazard ratio, 0.20; P = 0.03).

"Higher 25(OH)D concentrations were associated with a dose-response decrease in risk, with concentrations ≥60 ng/mL being most protective," the authors write.

Bio-Tech Pharmacal, Pure North S'Energy Foundation, and the Vitamin D Society funded the study.

Explore further: Greater levels of vitamin D associated with decreasing risk of breast cancer

More information: Abstract/Full Text

Related Stories

Greater levels of vitamin D associated with decreasing risk of breast cancer

June 15, 2018
Researchers at University of California San Diego School of Medicine suggest higher levels of vitamin D are associated with decreasing risk of breast cancer. Their epidemiological study is published in the June 15 online ...

Vit D concentration associated with reduced risk of cancer

March 14, 2018
(HealthDay)—Higher plasma concentration of 25-hydroxyvitamin D is associated with reduced risk of total cancer in a Japanese population, according to a study published online March 7 in The BMJ.

Increased adiposity tied to lower premenopausal breast CA risk

June 25, 2018
(HealthDay)—Across body mass index (BMI) distribution, increased BMI is associated with reduced risk of premenopausal breast cancer, according to a study published online June 21 in JAMA Oncology.

Large international study links blood vitamin D levels to colorectal cancer risk

June 14, 2018
A new study authored by scientists from the American Cancer Society, the Harvard T.H. Chan School of Public Health, the U.S. National Cancer Institute, and more than 20 other medical centers and organizations finds that higher ...

Higher levels of vitamin D correspond to lower cancer risk, researchers say

April 6, 2016
Researchers at University of California, San Diego School of Medicine report that higher levels of vitamin D - specifically serum 25-hydroxyvitamin D - are associated with a correspondingly reduced risk of cancer. The findings ...

High serum 25(OH)D linked to lower breast cancer mortality

March 14, 2014
(HealthDay)—Higher concentrations of serum 25-hydroxyvitamin D (25[OH]D) are associated with lower mortality from breast cancer, according to a meta-analysis published in the March issue of Anticancer Research.

Recommended for you

Researchers identify a mechanism that fuels cancer cells' growth

November 14, 2018
Scientists at the UCLA Jonsson Comprehensive Cancer Center have identified sodium glucose transporter 2, or SGLT2, as a mechanism that lung cancer cells can utilize to obtain glucose, which is key to their survival and promotes ...

A new approach to detecting cancer earlier from blood tests: study

November 14, 2018
Cancer scientists led by principal investigator Dr. Daniel De Carvalho at Princess Margaret Cancer Centre have combined "liquid biopsy", epigenetic alterations and machine learning to develop a blood test to detect and classify ...

New antibody breakthrough to lead the fight against cancer

November 14, 2018
Scientists at the University of Southampton have developed a new antibody that could hold the key to unlocking cancer's defence against the body's immune system.

Photoacoustic imaging may help doctors detect ovarian tumors earlier

November 14, 2018
Ovarian cancer claims the lives of more than 14,000 in the U.S. each year, ranking fifth among cancer deaths in women. A multidisciplinary team at Washington University in St. Louis has found an innovative way to use sound ...

Solving the mystery of NPM1 in acute myeloid leukemia

November 13, 2018
Although it has long been recognized that mutations of gene NPM1 play an important role in acute myeloid leukemia, no one has determined how the normal and the mutated forms of the protein NPM1 function.

Cognitive decline—radiation—brain tumor prevented by temporarily shutting down immune response

November 13, 2018
Treating brain tumors comes at a steep cost, especially for children. More than half of patients who endure radiation therapy for these tumors experience irreversible cognitive decline, a side-effect that has particularly ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.