HPV cervical CA screening cuts odds of later CIN3+ diagnosis

HPV cervical CA screening cuts odds of later CIN3+ diagnosis
(HealthDay)—The use of primary human papillomavirus (HPV) testing versus cytology results in reduced likelihood of cervical intraepithelial neoplasia (CIN) grade 3 or worse (CIN3+) at 48 months, according to a study published in the July 3 issue of the Journal of the American Medical Association.

Gina Suzanne Ogilvie, M.D., from the University of British Columbia in Vancouver, Canada, and colleagues conducted a randomized trial to assess histologically confirmed cumulative incident CIN3+ detected up to and including 48 months by HPV testing alone or liquid-based cytology. Overall, 19,009 women were randomized to the intervention and control groups (9,552 and 9,457, respectively). Women in the intervention received HPV testing, while those in the control group received liquid-based cytology testing.

Overall, 8,296 and 8,078 in the intervention and control groups, respectively, completed the study. The researchers found that significantly fewer CIN3+ and CIN2+ were detected in the intervention versus the at 48 months. Per 1,000 women, the incidence rates were 2.3 and 5.5 for CIN3+ in the intervention and control groups, respectively; the corresponding rates for CIN2+ were 5.0 and 10.6 (risk ratios, 0.42 and 0.47).

"Among women undergoing cervical cancer screening, the use of primary HPV testing compared with cytology testing resulted in a significantly lower likelihood of CIN3+ at 48 months," the authors write. "Further research is needed to understand long-term clinical outcomes as well as cost-effectiveness."

Several authors disclosed financial ties to the pharmaceutical industry.


Explore further

Low incidence of cervical cancer, CIN3+ for HPV-negative women

More information: Abstract/Full Text
Editorial (subscription or payment may be required)

Copyright © 2018 HealthDay. All rights reserved.

Citation: HPV cervical CA screening cuts odds of later CIN3+ diagnosis (2018, July 4) retrieved 21 May 2019 from https://medicalxpress.com/news/2018-07-hpv-cervical-ca-screening-odds.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
3 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more