Increased levels of human herpesvirus ID'd in Alzheimer's

July 30, 2018

(HealthDay)—Subjects with Alzheimer's disease have increased levels of two strains of human herpesvirus, according to a study published online July 11 in Neuron.

Ben Readhead, M.B.B.S., from the Icahn School of Medicine at Mount Sinai in New York City, and colleagues constructed multiscale networks of the late-onset Alzheimer's disease-associated virome, integrating genomic, transcriptomic, proteomic, and histopathological data across four using tissue from human postmortem samples.

The researchers found that, compared with controls, subjects with Alzheimer's disease had increased human herpesvirus 6A (HHV-6A) and HHV-7. In two additional, independent, and geographically dispersed cohorts, these results were replicated. Regulatory relationships were seen linking viral abundance and modulators of APP metabolism; HHV-6A induced APBB2, APPBP2, BIN1, BACE1, CLU, PICALM, and PSEN1.

"This study represents a significant advancement in our understanding of the plausibility of the pathogen hypothesis of Alzheimer's," a coauthor said in a statement. "If it becomes evident that specific viral species directly contribute to an individual's risk of developing Alzheimer's or their rate of progression once diagnosed, then this would offer a new conceptual framework for understanding the emergence and evolution of Alzheimer's at individual, as well as population, levels."

Explore further: Asymmetrical neuron loss in Alzheimer's

More information: Abstract/Full Text

Related Stories

Asymmetrical neuron loss in Alzheimer's

June 29, 2018
As Alzheimer's disease progresses, neuron loss leads to marked lateral asymmetries in brain structure. A new LMU study has now identified genetic variants that promote the emergence of asymmetrical brain atrophy in Alzheimer's ...

Genes linked to Alzheimer's contribute to damage in different ways

June 12, 2018
Multiple genes are implicated in Alzheimer's disease. Some are linked to early-onset Alzheimer's, a condition that develops in one's 30s, 40s and 50s, while others are associated with the more common late-onset form of the ...

New study suggests viral connection to Alzheimer's disease

June 21, 2018
Of the major illnesses facing humanity, Alzheimer's disease (AD) remains among the most pitiless and confounding. Over a century after its discovery, no effective prevention or treatment exists for this progressive deterioration ...

Vitamin C deficiency and mitochondrial dysfunction in Alzheimer's disease

December 4, 2017
Early clinical features of sporadic Alzheimer's disease include alterations in mitochondrial function that appear prior to classical features. Mitochondrial dysfunction increases the production of reactive oxygen species ...

Research points to new treatment strategy against Alzheimer's disease

September 7, 2016
New research suggests that Alzheimer's disease may trigger increased expression of an enzyme called lysozyme, which attempts to counteract amyloid build-up in the brain.

Changes in epigenetic DNA functions reveal how diabetes predisposes individuals to Alzheimer's

October 23, 2013
Diabetes and dementia are rising dramatically in the United States and worldwide. In the last few years, epidemiological data has accrued showing that older people with diabetes are significantly more likely to develop cognitive ...

Recommended for you

New discoveries predict ability to forecast dementia from single molecule

December 11, 2018
Scientists who recently identified the molecular start of Alzheimer's disease have used that finding to determine that it should be possible to forecast which type of dementia will develop over time—a form of personalized ...

Researchers classify Alzheimer's patients in six subgroups

December 5, 2018
Researchers studying Alzheimer's disease have created an approach to classify patients with Alzheimer's disease, a finding that may open the door for personalized treatments.

Neuroscientists pinpoint genes tied to dementia

December 3, 2018
A UCLA-led research team has identified genetic processes involved in the neurodegeneration that occurs in dementia—an important step on the path toward developing therapies that could slow or halt the course of the disease. ...

Detecting signs of neurodegeneration earlier and more accurately

November 30, 2018
Signs of neurodegenerative diseases, appearing years before the emergence of clinical manifestations, can be detected during the examination of medical samples by means of fluorescence microscopy by using new sensitive and ...

Never-before-seen DNA recombination in the brain linked to Alzheimer's disease

November 21, 2018
Scientists from Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified gene recombination in neurons that produces thousands of new gene variants within Alzheimer's disease brains. The study, published today ...

New information on the pathological mechanisms of Alzheimer's disease

November 21, 2018
Researchers at the University of Helsinki have discovered a mechanism by which harmful tau protein aggregates are transmitted between neurons. Alongside amyloid plaques, tau aggregates in the brain are a significant factor ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.