IV acetaminophen minimally helpful for colectomy pain

July 8, 2018

(HealthDay)—Intravenous acetaminophen does not decrease opioid utilization to a clinically significant threshold among colectomy patients, according to a study published in the July issue of Anesthesiology.

Isaac Wasserman, M.P.H., from the Icahn School of Medicine at Mount Sinai in New York City, and colleagues used national claims data from open colectomy (Premier Healthcare Database; 2011 to 2016; 181,640 patients at 602 hospitals) to assess oral and intravenous use on the day of , postoperative day one, or later. Associations between intravenous or oral acetaminophen and opioid utilization and opioid-related were evaluated.

The researchers found that 25.1 percent of patients received intravenous acetaminophen, with 48.0 percent of these patients receiving one dose on the day of surgery. More than one dose of intravenous acetaminophen on postoperative day one was associated with lower opioid utilization (−12.4 percent) versus non-use, while an even stronger reduction was seen in those receiving more than one oral acetaminophen dose (−22.6 percent). Differences in intravenous acetaminophen were less pronounced than oral on the day of surgery (−8.0 percent), which was statistically, but not clinically, significant. Similar outcome patterns were seen for opioid-related adverse effects.

"It is important that we identify optimal dosing strategies and patients that are most likely to benefit from this relatively new drug. Especially among patients undergoing colorectal surgery, there may be a group of patients that do not tolerate oral medications," coauthor Jashvant Poeran, M.D., Ph.D., also of the Icahn School of Medicine at Mount Sinai, said in a statement. "This may be less of an issue among patients undergoing other types of surgery, such as hip and knee replacement surgery, and these results further emphasize a more targeted approach in determining who benefits most."

Explore further: Intravenous acetaminophen has limited benefit for colectomy patients, study finds

More information: Abstract/Full Text

Related Stories

Intravenous acetaminophen has limited benefit for colectomy patients, study finds

June 18, 2018
Intravenous (IV) acetaminophen is no more effective than oral acetaminophen for patients undergoing colorectal procedures, Mount Sinai researchers report in a first-of-its-kind study. These findings suggest that eliminating ...

Opioids plus acetaminophen, ketorolac cost-effective post-Sx

February 15, 2018
(HealthDay)—Intravenous acetaminophen with or without ketorolac is associated with reduced opioid consumption and cost of care after scoliosis surgery in adolescents, compared with opioids alone, according to a study published ...

Celecoxib lowers opioid use post head and neck cancer surgery

April 23, 2018
(HealthDay)—For patients undergoing head and neck cancer (HNC) surgery, perioperative use of celecoxib is associated with reduced use of opioids after surgery, according to a study published online April 18 in JAMA Otolaryngology-Head ...

Acetaminophen may help reduce postoperative shivering

October 22, 2017
Administering acetaminophen, such as Tylenol, during surgery may reduce the incidence of postoperative shivering, suggests a study being presented at the ANESTHESIOLOG 2017 annual meeting.

Early post-op APAP exposure may cut AKI risk in peds cardiac Sx

May 15, 2018
(HealthDay)—For pediatric patients undergoing cardiac surgery, early postoperative acetaminophen exposure may be associated with a reduced rate of acute kidney injury (AKI), according to a study published online May 14 ...

Benefit of liposomal bupivacaine for pain in TKA questioned

June 4, 2018
(HealthDay)—Liposomal bupivacaine use in patients undergoing total knee arthroplasty is not associated with clinically meaningful reductions in inpatient opioid use, resource utilization, or opioid-related complications, ...

Recommended for you

3-D-printed tracheal splints used in groundbreaking pediatric surgery

September 19, 2018
Children's Healthcare of Atlanta has performed Georgia's first-ever procedure to place 3-D-printed tracheal splints in a pediatric patient. A cross-functional team of Children's surgeons used three custom-made splints, which ...

Muscle relaxants increase risk of respiratory complications

September 18, 2018
Muscle relaxants are a necessary part of anesthesia during certain major operations. However, studies have hinted at respiratory risks connected with these drugs. POPULAR, a major prospective observational European study ...

Gunshot victims require much more blood and are more likely to die than other trauma patients

September 17, 2018
In a new analysis of data submitted to Maryland's state trauma registry from 2005 to 2017, Johns Hopkins Medicine researchers found that gunshot victims are approximately five times more likely to require blood transfusions, ...

Liver allocation system disadvantages children awaiting transplants

September 17, 2018
Children are at a considerable disadvantage when competing with adults for livers from deceased organ donors in the U.S. allocation system, a University of Pittsburgh Graduate School of Public Health-led analysis reveals ...

Taste preferences connected to success of long-term weight loss after bariatric surgery

September 16, 2018
Following Roux-en-Y gastric bypass (RYGB), a type of bariatric surgery, many patients exhibit a reduction in taste preference for sweet and fatty foods, although this effect may only be temporary, according to new research ...

New insights into what drives organ transplant rejection

September 6, 2018
When it comes to transplant rejection, some organs are far trickier than others. Some transplantable organs, such as the liver, are readily accepted by the recipient's immune system, rarely triggering an immune response and ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.