Multiple factors to consider when selecting NSAID for arthritis

July 17, 2018

(HealthDay)—Factors to be considered when choosing the correct nonsteroidal anti-inflammatory drug (NSAID) for arthritis include effectiveness, concurrent health conditions, and frequency of use, according to a blog post published by the Arthritis Foundation.

When a patient requires an NSAID for muscle or joint pain associated with arthritis, finding an effective NSAID can be a matter of trial and error. Responses to drugs differ between patients, and it may be necessary to try multiple NSAIDs.

A patient's pre-existing should be considered when selecting an NSAID. NSAIDs interfere with the COX-1 enzyme, which is involved in protecting the lining of the gastrointestinal (GI) tract, and consequently NSAIDs may cause GI problems. Celecoxib is an exception, as it is a selective COX-2 inhibitor. Patients with a history of GI bleeding or stomach problems with traditional NSAIDs should use celecoxib. NSAID use is also associated with increased risk for attack and stroke, especially among those with existing heart disease or traditional risk factors. Certain NSAIDs may be safer for the heart, although the results of studies conducted have been inconclusive. Celecoxib has been found not to increase the risk of or stroke above that of naproxen or ibuprofen. NSAIDs should not be used among people with certain health conditions, including kidney disease, heart disease, or stomach ulcers. Although many NSAIDs must be taken every four hours, some come in long-acting or extended release forms. These can be taken as infrequently as once per day, which may be desirable for taking multiple medications.

Reduce the "risks of GI or cardiovascular problems by taking the lowest effective dose of an NSAID for the shortest time possible," according to the article.

Explore further: Which pain medication is safest for arthritis patients?

More information: More Information

Related Stories

Which pain medication is safest for arthritis patients?

April 19, 2018
In a recent Alimentary Pharmacology & Therapeutics study, arthritis patients taking nonsteroidal anti-inflammatory drugs (NSAIDs) for pain plus a stomach acid-reducing medicine called esomeprazole had infrequent gastrointestinal ...

Risk of heart disease associated with NSAIDs

May 8, 2017
Dear Mayo Clinic: Is it true that taking prescription-strength nonsteroidal anti-inflammatory drugs, or NSAIDs, can increase my risk of heart disease? How much is too much, and should I be concerned about regularly taking ...

Do pain medications carry different heart risks?

February 22, 2018
Prior studies have suggested that non-steroidal anti-inflammatory drugs (NSAIDs) may be linked with higher cardiovascular risks, but few have assessed potential different cardiovascular risk between NSAID classes or across ...

Trial reveals differences in pain-relieving drugs when combined with aspirin

April 16, 2018
A landmark 2016 Cleveland Clinic study of widely used pain-relieving drugs showed that celecoxib (Celebrex) was associated with comparable cardiovascular safety and better gastrointestinal (GI) and kidney safety when compared ...

Researchers determine the best strategy for preventing ulcers when taking NSAIDs

May 13, 2016
Non-steroidal anti-inflammatory drugs (NSAIDs)—including ibuprofen, diclofenac, naproxen and others—are commonly used pain medications that are generally safe but may increase the risk of developing stomach and intestinal ...

Soy lecithin NSAID combo drug protects against cancer with fewer side effects

May 30, 2018
When scientists at The University of Texas Health Science Center at Houston (UTHealth) applied a chemical found in soybeans to a non-steroidal anti-inflammatory drug (NSAID), they increased its anticancer properties and reduced ...

Recommended for you

US approves first generic competitor to Mylan's EpiPen

August 16, 2018
US regulators Thursday approved the first generic alternative for the EpiPen, a life-saving emergency allergy medicine, two years after soaring prices for the original version owned by Mylan stoked controversy.

Study: What patients really think about opioid vs non-opioid medications for chronic pain

August 14, 2018
Prescriptions of opioids for chronic pain has increased dramatically since the 1990s in spite of their known harms. Despite a shortage of scientific studies on the long-term effectiveness of opioids such as morphine, oxycodone ...

Doctors nudged by overdose letter prescribe fewer opioids

August 9, 2018
In a novel experiment, doctors got a letter from the medical examiner's office telling them of their patient's fatal overdose. The response: They started prescribing fewer opioids.

Benzodiazepine and related drug prescriptions have increased among young people in Sweden

August 7, 2018
The prevalence rate of prescriptions for benzodiazepines and benzodiazepine-related drugs (BZD)—medications used to treat anxiety, insomnia, epilepsy and other neuropsychiatric conditions—increased by 22% between 2006 ...

Unwise opioids for wisdom teeth: Study shows link to long-term use in teens and young adults

August 7, 2018
Getting wisdom teeth removed may be a rite of passage for many teens and young adults, but the opioid painkiller prescriptions that many of them receive could set them on a path to long-term opioid use, a new study finds.

Behavioral nudges lead to striking drop in prescriptions of potent antipsychotic

August 1, 2018
A study led by Columbia University's Mailman School of Public Health has found that letters targeting high prescribers of Seroquel (quetiapine), an antipsychotic with potentially harmful side effects in the elderly, significantly ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.