Multiple factors to consider when selecting NSAID for arthritis

July 17, 2018

(HealthDay)—Factors to be considered when choosing the correct nonsteroidal anti-inflammatory drug (NSAID) for arthritis include effectiveness, concurrent health conditions, and frequency of use, according to a blog post published by the Arthritis Foundation.

When a patient requires an NSAID for muscle or joint pain associated with arthritis, finding an effective NSAID can be a matter of trial and error. Responses to drugs differ between patients, and it may be necessary to try multiple NSAIDs.

A patient's pre-existing should be considered when selecting an NSAID. NSAIDs interfere with the COX-1 enzyme, which is involved in protecting the lining of the gastrointestinal (GI) tract, and consequently NSAIDs may cause GI problems. Celecoxib is an exception, as it is a selective COX-2 inhibitor. Patients with a history of GI bleeding or stomach problems with traditional NSAIDs should use celecoxib. NSAID use is also associated with increased risk for attack and stroke, especially among those with existing heart disease or traditional risk factors. Certain NSAIDs may be safer for the heart, although the results of studies conducted have been inconclusive. Celecoxib has been found not to increase the risk of or stroke above that of naproxen or ibuprofen. NSAIDs should not be used among people with certain health conditions, including kidney disease, heart disease, or stomach ulcers. Although many NSAIDs must be taken every four hours, some come in long-acting or extended release forms. These can be taken as infrequently as once per day, which may be desirable for taking multiple medications.

Reduce the "risks of GI or cardiovascular problems by taking the lowest effective dose of an NSAID for the shortest time possible," according to the article.

Explore further: Which pain medication is safest for arthritis patients?

More information: More Information

Related Stories

Which pain medication is safest for arthritis patients?

April 19, 2018
In a recent Alimentary Pharmacology & Therapeutics study, arthritis patients taking nonsteroidal anti-inflammatory drugs (NSAIDs) for pain plus a stomach acid-reducing medicine called esomeprazole had infrequent gastrointestinal ...

Risk of heart disease associated with NSAIDs

May 8, 2017
Dear Mayo Clinic: Is it true that taking prescription-strength nonsteroidal anti-inflammatory drugs, or NSAIDs, can increase my risk of heart disease? How much is too much, and should I be concerned about regularly taking ...

Do pain medications carry different heart risks?

February 22, 2018
Prior studies have suggested that non-steroidal anti-inflammatory drugs (NSAIDs) may be linked with higher cardiovascular risks, but few have assessed potential different cardiovascular risk between NSAID classes or across ...

Trial reveals differences in pain-relieving drugs when combined with aspirin

April 16, 2018
A landmark 2016 Cleveland Clinic study of widely used pain-relieving drugs showed that celecoxib (Celebrex) was associated with comparable cardiovascular safety and better gastrointestinal (GI) and kidney safety when compared ...

Researchers determine the best strategy for preventing ulcers when taking NSAIDs

May 13, 2016
Non-steroidal anti-inflammatory drugs (NSAIDs)—including ibuprofen, diclofenac, naproxen and others—are commonly used pain medications that are generally safe but may increase the risk of developing stomach and intestinal ...

Soy lecithin NSAID combo drug protects against cancer with fewer side effects

May 30, 2018
When scientists at The University of Texas Health Science Center at Houston (UTHealth) applied a chemical found in soybeans to a non-steroidal anti-inflammatory drug (NSAID), they increased its anticancer properties and reduced ...

Recommended for you

Health insurer policies may discourage use of non-opioid alternatives for lower back pain

October 5, 2018
Public and private health insurance policies in the U.S. are missing important opportunities to encourage the use of physical therapy, psychological counseling and other non-drug alternatives to opioid medication for treating ...

Opioid overdoses, depression linked

October 3, 2018
The link between mental health disorders and substance abuse is well-documented. Nearly one in 12 adults in the U.S is depressed, and opioid-related deaths are skyrocketing. As these numbers continue to climb, some mental ...

Do price spikes on some generic drugs indicate problems in the market?

October 1, 2018
A new USC study reports that sudden price spikes for some generic drugs—such as the recently reported increases of a decades-old generic heart medication and an antibiotic—are becoming more common.

Reclassification recommendations for drug in 'magic mushrooms'

September 26, 2018
In an evaluation of the safety and abuse research on the drug in hallucinogenic mushrooms, Johns Hopkins researchers suggest that if it clears phase III clinical trials, psilocybin should be re-categorized from a schedule ...

New study finds concurrent use of prescription drugs and dietary supplements could pose health risks

September 25, 2018
A new University of Hertfordshire study found that using certain over-the-counter herbal medicines and dietary supplements alongside prescription drugs could pose serious health risks, especially amongst older adults.

Drug overdose epidemic has been growing exponentially for decades

September 20, 2018
Death rates from drug overdoses in the U.S. have been on an exponential growth curve that began at least 15 years before the mid-1990s surge in opioid prescribing, suggesting that overdose death rates may continue along this ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.