Polio-rhinovirus promising for malignant glioma patients
Annick Desjardins, M.D., from Duke University Medical Center in Durham, N.C., and colleagues conducted a dose-finding and toxicity study among 61 consecutive adult patients who had recurrent World Health Organization (WHO) grade IV malignant glioma. The authors evaluated seven doses of convection-enhanced, intratumoral delivery of PVSRIPO in a dose-escalation phase and a dose-expansion phase.
Dose level −1 (5.0107 TCID50) was identified as the phase 2 dose. The researchers found that one dose-limiting toxic effect (a grade 4 intracranial hemorrhage immediately after the catheter was removed) was observed in a patient receiving dose level 5 (1010 TCID50). Dose level 5 was de-escalated to reach the phase 2 dose to mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use. Overall, 19 percent of patients had a PVSRIPO-related adverse event of grade 3 or higher in the dose-expansion phase. A plateau of 21 percent overall survival among the patients who received PVSRIPO was reached at 24 months and sustained to 36 months.
Several authors disclosed financial ties to the pharmaceutical industry and/or hold patents related to treating tumors with oncolytic poliovirus.
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