Long-term PPI use linked to pneumonia risk in older adults
Jan Zirk-Sadowski, Ph.D., from the University of Exeter in the United Kingdom, and colleagues assessed associations between long-term use of PPIs and pneumonia incidence. The analysis included 75,050 older adults (≥60 years) who were in primary care and had been receiving PPIs for at least one year and 75,050 age- and sex-matched controls.
The researchers found that during the second year after initiating treatment, PPIs were associated with greater hazard of incident pneumonia (prior event rate ratio-adjusted hazard ratio, 1.82), accounting for pretreatment pneumonia rates. Across age and comorbidity subgroups, estimates were similar.
"Controversies about the validity of reported short-term harms of PPIs should not divert attention from potential long-term effects of PPI prescriptions on older adults," the authors write.
One author disclosed financial ties to the pharmaceutical industry.
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