Tamsulosin does not appear to promote urinary stone passage

Tamsulosin does not appear to promote urinary stone passage
(HealthDay)—Tamsulosin does not significantly increase the urinary stone passage rate compared with placebo, according to a study published online June 18 in JAMA Internal Medicine.

Andrew C. Meltzer, M.D., from the George Washington University School of Medicine & Health Sciences in Washington, D.C., and colleagues randomized 512 patients presenting in an emergency department with symptomatic urinary stone in the ureter (<9 mm in diameter) to treatment with either tamsulosin (0.4 mg) or placebo daily for 28 days.

The researchers found that stone passage rates were 50 percent in the tamsulosin group and 47 percent in the placebo group (relative risk, 1.05; 95.8 percent confidence interval, 0.87 to 1.27; P = 0.60). No secondary outcomes (time to stone passage, return to work, use of analgesic medication, hospitalization, surgical intervention, and repeated emergency department visit) were significant.

"For patients who present with renal colic owing to ureteral stones smaller than 9 mm, tamsulosin does not appear to promote stone passage," the authors write. "Guidelines for medical expulsive therapy for urinary stones may need to be revised."

Explore further

Recent clinical trial finds tamsulosin not effective in kidney stone passage

More information: Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Journal information: JAMA Internal Medicine

Copyright © 2018 HealthDay. All rights reserved.

Citation: Tamsulosin does not appear to promote urinary stone passage (2018, August 1) retrieved 23 May 2019 from https://medicalxpress.com/news/2018-08-tamsulosin-urinary-stone-passage.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more