WHO issues recommendations for Tx intensification in T2DM

WHO issues recommendations for tx intensification in T2DM

(HealthDay)—Recommendations have been developed by the World Health Organization for treatment intensification in type 2 diabetes. The recommendations were published online Sept. 4 in the Annals of Internal Medicine.

Gojka Roglic, M.D., and Susan L. Norris, M.D., M.P.H., from the World Health Organization in Switzerland, developed recommendations to provide guidance on medicine selection for treatment intensification in type 2 , and use of insulin in type 1 and 2 diabetes.

The researchers developed five recommendations. One, a sulfonylurea should be given to patients with type 2 diabetes who do not achieve glycemic control with metformin alone or who have contraindications to metformin. Two, human insulin treatment should be introduced to patients with type 2 diabetes who do not achieve with metformin and/or a sulfonylurea. Three, a dipeptidyl peptidase-4 inhibitor, a sodium-glucose contransporter-2 inhibitor, or a thiazolidinedione may be added if insulin is unsuitable. Four, in adults with type 1 diabetes, and in adults with type 2 diabetes for whom insulin is indicated, human insulin should be used to manage blood glucose. Five, long-acting insulin analogues should be considered to manage in adults with type 1 or type 2 diabetes who have frequent, severe hypoglycemia with human insulin.

"The decision to name sulfonylureas as the single best second-line agent largely reflects the prioritization of cost and the recognition that WHO guidelines must apply to low-resource settings," write the authors of an accompanying editorial.

More information: Abstract/Full Text
Editorial (subscription or payment may be required)

Journal information: Annals of Internal Medicine

Copyright © 2018 HealthDay. All rights reserved.

Citation: WHO issues recommendations for Tx intensification in T2DM (2018, September 5) retrieved 2 October 2023 from https://medicalxpress.com/news/2018-09-issues-tx-intensification-t2dm.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

ADA recommends metformin as the preferred drug treatment for type 2 diabetes


Feedback to editors