NIRS-IVUS detects patients and plaques vulnerable to subsequent adverse coronary events

Results from the Lipid-Rich Plaque (LRP) study demonstrate the correlation between the presence of non-flow-limiting, non-intervened upon, lipid-rich plaques detected by NIRS-IVUS imaging and the development of a major adverse cardiac event (MACE) from a de novo culprit lesion at both the patient level (vulnerable patients) and segment level (vulnerable plaques) within 24 months post intravascular imaging.

Findings were reported today at the 30th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT is the world's premier educational meeting specializing in interventional cardiovascular medicine.

Coronary lipid-rich plaques may be associated with subsequent cardiovascular events and it has been hypothesized that the outcome post-PCI could be improved by the detection and subsequent treatment of vulnerable and lipid-rich vulnerable coronary plaques. Intravascular near-infrared spectroscopy (NIRS) is available as a dual modality catheter with simultaneous, co-registered intravascular ultrasound (IVUS).

From February 2014 to March 2016, a total of 1,563 patients with suspected who underwent with PCI for an index event were enrolled at 44 sites in the United States and Europe. Imaging by NIRS-IVUS was performed in two or more arteries and patient level and plaque level events were detected for two years. All patients with at least one maxLCBI4mm segment greater than or equal to 250 and a randomly selected 50% of patients with all maxLCBI4mm segments less than 250 were followed.

In the vulnerable patient-level analysis, the risk of experiencing non-culprit MACE event within 24 months was 18% higher with each 100 unit increase in maxLCBI4mm. Patients with maxLCBI4mm ≥400 had a MACE rate of 12.6% compared with 6.3% for patients with maxLCBI4mm˂400. In the vulnerable plaque-level analysis, the risk of experiencing an event in a coronary segment within 24 months was 45% higher with each 100 unit increase in maxLCBI4mm. Plaque with maxLCBI4mm ≥400 had a MACE rate of 3.7% compared to 0.8% for with maxLCBI4mm˂400.

"Multi-vessel NIRS can be easily and safely performed to assess and identify vulnerable patients and vulnerable plaques," said Ron Waksman, MD, associate director of the Division of Cardiology at MedStar Heart Institute in Washington, D.C. "Intravascular NIRS imaging in mildly or non-obstructive coronary arteries can be used as a tool to identify both patients and non-culprit arteries at high risk for future events and should be considered for use in patients undergoing cardiac catheterization with possible PCI."


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Citation: NIRS-IVUS detects patients and plaques vulnerable to subsequent adverse coronary events (2018, September 24) retrieved 13 November 2019 from https://medicalxpress.com/news/2018-09-nirs-ivus-patients-plaques-vulnerable-subsequent.html
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