ALS drug may help treat prostate cancer

October 3, 2018, Wiley
Micrograph showing prostatic acinar adenocarcinoma (the most common form of prostate cancer) Credit: Wikipedia

Researchers have discovered a new use for an old drug as a potential treatment for prostate cancer. The findings are published in the journal The Prostate.

Since the 1940s, androgens have been linked to , and decades of work since have focused on (AR), a nuclear receptor transcription factor. Although AR drives prostate cancer, inhibiting it induces remission for only a short time. Investigators have found that a drug approved for the treatment of amyotrophic lateral sclerosis—called riluzole—promotes the degradation of AR through a distinct pathway.

The findings suggest that riluzole should be investigated clinically for prostate cancer and predict that it may be effective for both and advanced disease," said senior author Dr. Shahriar Koochekpour, of Roswell Park Comprehensive Cancer Center.

Explore further: A new method for prostate cancer imaging

More information: Kristine M. Wadosky et al, Riluzole induces AR degradation via endoplasmic reticulum stress pathway in androgen-dependent and castration-resistant prostate cancer cells, The Prostate (2018). DOI: 10.1002/pros.23719

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Anonym897846
not rated yet Oct 23, 2018
I was diagnosed of ALS (Amyotrophic Lateral Sclerosis) 2013 in Parkland hospital, Dallas, i was given Rilutek (riluzole) to help my symptoms. In August 2014 my symptoms worsened, with no hope of a cure from my doctor and his medical team i looked out for an alternative treatment. I read on a website about Natural Herbal Gardens and their successful herbal treatment for ALS, i immediately contacted them via their website and purchased the ALS herbal remedy. I used the herbal remedy for 9 weeks, all my symptoms including difficulty walking, weakness in legs and arm, slurred speech etc miraculously disappeared, my speech is understandable now, its unbelievable, visit www. naturalherbalgardens. com. I had stopped working since i was diagnosed of ALS, i resumed working in 2016, I have control of my body ones again!

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