Immunity connects gut bacteria and aging

gut bacteria
Credit: CC0 Public Domain

Over the years, researchers have learned that the different populations of bacteria that inhabit the gut have significant effects on body functions, including the immune system. The populations of gut bacteria are sometimes called "commensal," and exist in virtually all animals living under a certain functional balance. When this balance is disrupted—for example, because of disease or medication—it gives rise to a condition known as "commensal dysbiosis," which is associated with a number of pathologies and even a decreased lifespan. Despite this knowledge, little is known about how, exactly, the gut bacteria affect general health and vice versa.

Now, Igor Iatsenko, a scientist from the lab of Bruno Lemaitre at EPFL's Global Health Institute, has discovered a mechanism by which problems of the immune system can cause commensal dysbiosis, which promotes age-related pathologies.

The team used the fruit-fly Drosophila melanogaster, which is often used to study the biology of gut bacteria. Because they wanted to explore the interplay between and the immune system, they focused on a receptor protein called peptidoglycan recognition protein SD (PGRP-SD). This protein belongs to a class of pattern-recognition receptors, and in 2016, Igor Iatsenko had showed that PGRP-SD detects foreign bacterial pathogens and turns the fly's immune system against them.

In the present study, the scientists turned off the gene for PGRP-SD, thus creating flies with disrupted immune systems. The mutant flies proved to have shorter lifespans than normal ones, and when the researchers examined them, they found that they also had an abnormally high number of the gut bacterium Lactobacillus plantarum.

Looking into the biological impact, the scientists found that the produced an excessive amount of lactic acid. This, in turn, triggered the generation of , which cause damage to cells and contribute to the aging of tissues. In contrast, when the scientists increased the production of PGRP-SD, they found that it prevented commensal dysbiosis, and even extended the lifespan of the flies.

"Here, we have a metabolic interplay between the and the host," says Bruno Lemaitre. "Lactic acid, a metabolite produced by the bacterium Lactobacillus plantarum, is incorporated and processed in the fly intestine, with the side-effect of producing reactive oxygen species that promote epithelial damage." The researchers speculate that similar mechanisms are taking place in the mammalian intestine.

"Our study identifies a specific microbiota member and its metabolite that can influence aging in the host organism," says Igor Iatsenko. "There are definitely many more examples like this, and a better understanding of host-microbiota metabolic interactions during aging is needed in order to develop strategies against age-associated pathologies."

Explore further

Drosophila innate immunity: Another piece to the puzzle

More information: Igor Iatsenko, Jean-Philippe Boquete, Bruno Lemaitre. Microbiota-derived lactate activates production of reactive oxygen species by the intestinal NADPH oxidase Nox and shortens Drosophila lifespan. Immunity 13 November 2018. DOI: 10.1016/j.immuni.2018.09.017
Journal information: Immunity

Citation: Immunity connects gut bacteria and aging (2018, November 13) retrieved 22 January 2020 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors

User comments