Research in male mice published in JNeurosci demonstrates activation of microglia in the spinal cord is responsible for increased pain sensitivity in response to stress.
John Sheridan and colleagues identified an inflammatory environment in the spinal cord caused by repeated exposure to an aggressive mouse—an established model of psychosocial stress—that accompanied lower pain thresholds observed in the stressed mice.
Stress increased expression of inflammatory genes and activation of microglia in spinal cord regions involved in pain processing. Eliminating microglia from the spinal cord prevented these effects.
These findings suggest a new cellular target for alleviating stress-induced pain.
Microglia transmit pain to the brain during stress (2018, December 17)
retrieved 20 January 2019
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.
Your feedback will go directly to Science X editors.
E-mail the story
Sodium-based batteries could make your smartphone cheaper and cleaner