Altered gut microbiome seen in patients with active lupus

Altered gut microbiome seen in patients with active lupus

(HealthDay)—The microbiome of patients with systemic lupus erythematosus (SLE), particularly those with increased disease activity, has reduced taxonomic complexity, according to a study published online Feb. 19 in the Annals of the Rheumatic Diseases.

Doua Azzouz, Ph.D., from the New York University (NYU) School of Medicine in New York City, and colleagues obtained matched blood and from 61 with SLE. Fecal 16S rRNA analyses were performed, and sera were profiled for antibacterial and autoantibody responses. Findings were validated in two independent cohorts.

The researchers found that in patients with SLE, the microbiome showed decreased species richness diversity compared with controls; the most pronounced reductions in taxonomic complexity were seen for those with a high SLE disease activity index (SLEDAI). An overall fivefold greater representation of Ruminococcus gnavus (RG) of the Lachnospiraceae family was seen in patients with SLE; reciprocal contractions of a species with putative protective properties were also seen in individual communities. There was a correlation for gut RG abundance with to only one of eight RG strains tested. There was a direct correlation for anti-RG antibodies with SLEDAI score and antinative DNA levels, and there were inverse correlations with C3 and C4. Individuals with active nephritis had the highest levels of serum anti-RG strain-restricted antibodies in the discovery cohort; this finding was replicated in the validation cohorts.

"Our analyses provide the first evidence that lupus is associated with intestinal outgrowths of RG, an obligate anaerobic species," the authors write.

NYU has filed intellectual property related to this study.

More information: Abstract/Full Text

Journal information: Annals of the Rheumatic Diseases

Copyright © 2019 HealthDay. All rights reserved.

Citation: Altered gut microbiome seen in patients with active lupus (2019, February 20) retrieved 8 June 2023 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Lupus strongly linked to imbalances in gut microbiome


Feedback to editors