Mild congenital heart defects tied to CVD events

Mild congenital heart defects tied to CVD events

(HealthDay)—Individuals with lower-complexity adult congenital heart disease (ACHD) have a higher burden of adverse cardiovascular events than the general population, independent of conventional cardiovascular risk factors, according to a study published Feb. 28 in Circulation.

Priyanka Saha, from Stanford University School of Medicine in California, and colleagues attempted to quantify the risk for adverse cardiovascular events among 2,006 adults with lower-complexity ACHD compared with 497,983 adults without ACHD (median age, 58 years at enrollment) in the U.K. Biobank. Follow-up data were available for up to 22 years.

The researchers found that among the ACHD-diagnosed individuals, 69 percent were also diagnosed with or treated for hypertension, 41 percent were diagnosed with or treated for hyperlipidemia, and 7 percent were diagnosed with or treated for diabetes. ACHD remained strongly associated with fatal or nonfatal acute coronary syndrome (ACS), , (HF), and atrial fibrillation, even after adjustment for 12 cardiovascular risk factors (hazard ratios ranged from 2 for ACS to 13 for HF). ACHD-exposed individuals with no more than two cardiovascular risk factors had a 29 percent age-adjusted incidence rate of major adverse cardiovascular events versus 13 percent in non-ACHD individuals with at least five risk factors.

"These findings highlight the need for closer surveillance of patients with mild-to-moderate ACHD and further investigation into management and mechanisms of cardiovascular risk unique to this growing population of high-risk adults," the authors write.


Explore further

Guidelines updated for adult congenital heart disease

More information: Abstract/Full Text (subscription or payment may be required)
Journal information: Circulation

Copyright © 2019 HealthDay. All rights reserved.

Citation: Mild congenital heart defects tied to CVD events (2019, March 26) retrieved 22 August 2019 from https://medicalxpress.com/news/2019-03-mild-congenital-heart-defects-tied.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
2 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more