Niraparib extends time without symptoms in ovarian cancer

Niraparib extends time without symptoms in ovarian cancer

(HealthDay)—Women with recurrent ovarian cancer who receive the poly ADP ribose polymerase (PARP) inhibitor niraparib as maintenance therapy after treatment have both more time without side effects and significantly longer progression-free survival (PFS) than those on placebo, according to a study presented at the Society of Gynecologic Oncology Annual Meeting on Women's Cancer, held from March 16 to 19 in Honolulu.

Ursula A. Matulonis, M.D., from the Dana-Farber Cancer Institute in Boston, and colleagues estimated the time without symptoms or (TWiST) in 553 women receiving maintenance therapy with niraparib compared to those receiving placebo as part of the international ENGOT-OV16/NOVA phase 3 study. Symptomatic adverse events included grade ≥2 fatigue, nausea, and vomiting. Toxicity time was calculated as the number of days a patient experienced an adverse event after random assignment but prior to disease progression. TWiST was measured as the difference between mean PFS and mean toxicity time.

The researchers found that treatment with niraparib resulted in a mean PFS benefit of 3.23 years and a mean toxicity time of 0.28 years versus placebo in the germline BRCA1/2 mutated (gBRCAmut) cohort. In the non- gBRCAmut cohort, treatment with niraparib resulted in a mean PFS benefit of 1.44 years and a mean toxicity time of 0.10 years versus placebo. Treatment with niraparib compared with in the gBRCAmut and non-gBRCAmut cohorts yielded a mean TWiST benefit of 2.95 and 1.34 years, respectively.

"It's really important to demonstrate that, if we're adding a , we're not significantly altering women's quality of life," Matulonis said in a statement.


Explore further

Niraparib significantly improves outcome of ovarian cancer patients in landmark trial

More information: Press Release
More Information

Copyright © 2019 HealthDay. All rights reserved.

Citation: Niraparib extends time without symptoms in ovarian cancer (2019, March 22) retrieved 17 October 2019 from https://medicalxpress.com/news/2019-03-niraparib-symptoms-ovarian-cancer.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
1 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more