Shortages of essential medicines for pediatric cancer patients threaten outcomes

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Shortages of essential chemotherapy drugs for children undergoing cancer treatment has been an increasingly frequent obstacle for patients and hospitals across the country. In a new position paper in JAMA Pediatrics, Baylor College of Medicine's Drs. Stacey Berg and Brooke Bernhardt address this issue and call for the development of an essential medicines list for this group of patients to help ensure reliable access and forecast future shortages.

Shortages of essential medicines for childhood cancers can result in increased medication errors, delayed administration of life-saving therapy, inferior outcomes and patient deaths.

"All children, including those undergoing treatment for cancer, have a fundamental right to healthcare, and these drug shortages compromise that right," said Berg, professor of pediatrics – hematology and oncology at Baylor and Texas Children's Hospital. "Essential medicines lists are used in other countries, but one has yet to be established for the United States, which could help alleviate this economic and healthcare burden domestically."

In addition to compiling a list of essential drugs, the authors also provide recommendations on what to do when there are shortages, as well as how to forecast need in the future.

"We need a more active planning process," said Berg, who also is associate dean for research assurances and member of the Dan L Duncan Comprehensive Cancer Center at Baylor. "These medicines should be considered in healthcare, and this approach has implications beyond pediatric oncology; children with other serious diseases should have access to evidence-based medicines that are deemed essential to preserve life and function."

Many of these agents are relatively inexpensive, and often are generic, Berg explained, so it can be challenging to capture the attention of the big pharmaceutical companies. "We hope this list will help educate families that their are potentially at risk and galvanize the public to pressure for legislative change and increased involvement from the Food and Drug Administration in preventing and managing shortages of essential medicines."

More information: Yoram Unguru et al. Chemotherapy and Supportive Care Agents as Essential Medicines for Children With Cancer, JAMA Pediatrics (2019). DOI: 10.1001/jamapediatrics.2019.0070

Journal information: JAMA Pediatrics
Citation: Shortages of essential medicines for pediatric cancer patients threaten outcomes (2019, March 5) retrieved 23 May 2024 from
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