In vivo data show effects of spaceflight microgravity on stem cells and tissue regeneration

In vivo data show effects of spaceflight microgravity on stem cells and tissue regeneration
Credit: Mary Ann Liebert, Inc., publishers

A new review of data from 12 spaceflight experiments and simulated microgravity studies has shown that microgravity does not have a negative effect on stem-like cell-dependent tissue regeneration in newts, but in some tissues regeneration is faster and more robust. This valuable in vivo data has implications for understanding and managing the ability for repair and regeneration of human tissues during spaceflight. The review is published in Stem Cells and Development.

The article entitled "Behavior of Stem-Like Cells, Precursors for Tissue Regeneration in Urodela, Under Conditions of Microgravity" was coauthored by Eleonora N. Grigoryan and Elena A. Radugina, Russian Academy of Sciences, Moscow. The researchers summarized their research conducted over many years in which they focused on the effects of microgravity on stem-like cells that served as the source for new eye, limb, and tail in newts, a vertebrate that has profound regenerative potential. Microgravity promoted stem-like cell proliferation by as much as 2-fold in some tissues, leading to the formation of bigger and more developed regenerates. Exposure to had relatively long-lasting effects.

"This insightful and comprehensive review allows the world's tissue engineering community access to 30 years of research on the primary model of vertebrate regeneration," says Editor-in-Chief Graham C. Parker, Ph.D., The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI.


Explore further

Effects of spaceflight on heart cell formation from stem cells

More information: Eleonora N. Grigoryan et al, Behavior of Stem-Like Cells, Precursors for Tissue Regeneration in Urodela, Under Conditions of Microgravity, Stem Cells and Development (2019). DOI: 10.1089/scd.2018.0220
Journal information: Stem Cells and Development

Citation: In vivo data show effects of spaceflight microgravity on stem cells and tissue regeneration (2019, March 25) retrieved 26 August 2019 from https://medicalxpress.com/news/2019-03-vivo-effects-spaceflight-microgravity-stem.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more