Our kidneys can sense when we need them to work a bit harder. As the intestines begin to produce more waste products, the kidneys start to work harder to excrete them. Researchers at, among others, Utrecht University and Universitair Ziekenhuis Leuven published an article on the process in PNAS on July, 22. Insight into this mechanism could lead to new treatments for kidney failure.
Kidneys filter waste products from the blood, and they can increase their filtering activity when necessary. But until now, scientists had not known exactly how this mechanism worked. The research group led by Roos Masereeuw has now shown that certain kidney cells have receptors that can observe higher concentrations of waste products. The group then identified how this observation stimulates the production of a transport protein, which results in increased excretion of the waste substances.
New treatments for kidney failure
According to Prof. Masereeuw, insight into this mechanism could lead to new treatments for kidney failure. This is because the mechanism plays a vital role in stimulating the excretion of waste; a process that is inhibited by kidney failure. "By jump-starting that mechanism, we think that we might be able to treat early-stage kidney failure," Masereeuw explains. "We're going to continue to study how we can initiate that process ourselves."
Made possible by artificial kidney tubules
One of the steps towards identifying this mechanism involved using artificial kidney vesicles, which Masereeuw had previously developed together with other researchers. This allowed the group to study which receptors and signal molecules at the cellular level are involved in observing the waste products and regulating the transport proteins that facilitate excretion in urine.
More information: Jitske Jansen el al. Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion.PNAS (2019). www.pnas.org/cgi/doi/10.1073/pnas.1821809116
Journal information: Proceedings of the National Academy of Sciences
Provided by Utrecht University Faculty of Science