Statin use reduces mortality and stroke risk in dementia patients, new study shows

The use of statins is significantly associated with a reduction in the risk of mortality in dementia patients, new research presented today at the 5th European Academy of Neurology (EAN) Congress has shown.

The study, which analysed 44,920 Swedish from the Swedish Dementia Registry between 2008-2015, found users of statins had a 22% of all-cause death compared to matched non-users.

The research also demonstrated that statin users had a 23% reduction in the risk of stroke, which is three times more likely in with and seven times more likely in those with severe .

The protective effect of statins on survival were strong for patients younger than 75 years (27% reduction) and in men (26% reduction) but women and also benefited (17% and 20% reduction respectively). Patients with —the second most common type of dementia after Alzheimer's disease—also saw a 29% lower mortality risk.

"Survival in patients in dementia is variable, and previous studies have identified many factors associated with survival and risk of stroke in these patients", commented first author Bojana Petek, MD, from the University Medical Center Ljubljana, Slovenia and the Karolinska Institutet, Sweden. "However, the effect of statins on these two outcomes is not clear. The aim of this study was to analyse the association between the use of statins on the risk of death and stroke in patients diagnosed with dementia."

Commenting on their research, lead author Dr. Sara Garcia-Ptacek from the Karolinska Institutet, Sweden, stated, "This is a cohort study, which means patients were not randomized to a treatment like they would be in a clinical trial. For this reason, we can only show an association, and not definitely prove that statins caused this decline in mortality. However, our results are encouraging and suggest that patients with dementia benefit from statins to a similar extent than patients without dementia."

Affecting around 10 million people in Europe, dementia is the leading cause of dependency and disability among older people across the continent. The number of cases is expected to double by 2030, largely due to the ageing population. The prevalence of dementia increases exponentially with age, affecting 5% of the population over 65, and up to 50% by 90 years of age.


Explore further

Statin use reduces dementia risk after concussion in seniors

Provided by The European Academy of Neurology
Citation: Statin use reduces mortality and stroke risk in dementia patients, new study shows (2019, July 1) retrieved 15 October 2019 from https://medicalxpress.com/news/2019-07-statin-mortality-dementia-patients.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
1 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more